Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yi-Shan Road, Shanghai, 200233, People's Republic of China.
Department of Materials Science, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, People's Republic of China.
J Biomed Mater Res A. 2018 May;106(5):1269-1275. doi: 10.1002/jbm.a.36326. Epub 2018 Jan 23.
Abdominal wall hernias are repaired with tension-free prosthetic materials but there remains a foreign body response (FBR) to commonly used polypropylene mesh. Thus, we should optimize mesh materials to improve the patient outcomes after surgery. A polypropylene mesh was developed with wrap knitting technique. The physical, mechanical and biocompatible characteristics were tested in a rat abdominal hernia model and compared to ULTRAPRO and Easy Prosthesis. Polypropylene mesh of two pore sizes was developed (LP-WKPM and SP-WKPM). Compared with ULTRAPRO and Easy Prosthesis mesh, the novel mesh were lighter, thinner, and stronger (p < 0.05). Among the four implanted mesh types, there were fewer inflammatory cells and foreign body giant cells surrounding LP-WKPM fibers (p < 0.05), and significantly fewer mononuclear cells and less neovascularization between LP-WKPM fibers (p < 0.05) On day 15, 30 and 90 after implantation there were no differences in foreign body giant cells compared to 15 days after implantation (p>0.05). We developed a novel large-pore lightweight polypropylene mesh that produced less FBR and better biocompatibility in an abdominal wall hernia model. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1269-1275, 2018.
腹壁疝采用无张力假体材料修复，但常用的聚丙烯网仍存在异物反应（FBR）。因此，我们应该优化网材，以改善手术后患者的预后。采用包缠编织技术开发了一种聚丙烯网。在大鼠腹壁疝模型中对其物理、机械和生物相容性特征进行了测试，并与 ULTRAPRO 和 Easy Prosthesis 进行了比较。开发了两种孔径的聚丙烯网（LP-WKPM 和 SP-WKPM）。与 ULTRAPRO 和 Easy Prosthesis 网相比，新型网更轻、更薄、更强（p<0.05）。在四种植入的网类型中，围绕 LP-WKPM 纤维的炎症细胞和异物巨细胞较少（p<0.05），LP-WKPM 纤维之间的单核细胞更少，新生血管形成也较少（p<0.05）。植入后 15、30 和 90 天，与植入后 15 天相比，异物巨细胞没有差异（p>0.05）。我们开发了一种新型大孔轻质聚丙烯网，在腹壁疝模型中产生较少的异物反应和更好的生物相容性。©2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1269-1275, 2018.
