接受头孢他啶（CAZ）或头孢噻肟（CTX）加妥布霉素（TOB）治疗的尿路感染患者的尿丙氨酸氨基肽酶（AAP）排泄情况。

Urinary alanine-aminopeptidase (AAP) excretion in patients with urinary tract infection treated with ceftazidime (CAZ) or cefotaxime (CTX) plus tobramycin (TOB).

作者信息

Wiecek A, Kokot F, Grzeszczak W

机构信息

Department of Nephrology, Silesian School of Medicine, Katowice, Poland.

出版信息

Int Urol Nephrol. 1988;20(5):461-70. doi: 10.1007/BF02550604.

DOI:10.1007/BF02550604

PMID:2906920

Abstract

It is well known that some antibiotics are particularly nephrotoxic. In the present study we investigated kidney function and AAP excretion (as an index of nephrotoxicity) in patients with urinary tract infection treated with CAZ or CTX plus TOB. The main cause of infection was E. coli in both treated groups. After 10 days of treatment similar beneficial effects were stated in both groups. At the end of treatment urinary AAP excretion in both groups was higher than before treatment. Despite a significant increase in urinary AAP in only one patient of each group, the serum creatinine level rose by more than 45 mumol/l. Monitoring of urinary AAP may be useful in early detection of nephrotoxicity caused by antibiotics.

摘要

众所周知，某些抗生素具有特别的肾毒性。在本研究中，我们调查了接受头孢他啶（CAZ）或环磷酰胺（CTX）加妥布霉素（TOB）治疗的尿路感染患者的肾功能和氨基乙酰丙酸（AAP）排泄情况（作为肾毒性指标）。两个治疗组感染的主要原因均为大肠杆菌。治疗10天后，两组均显示出相似的有益效果。治疗结束时，两组的尿AAP排泄量均高于治疗前。尽管每组仅1例患者的尿AAP显著升高，但血清肌酐水平升高超过45μmol/L。监测尿AAP可能有助于早期发现抗生素引起的肾毒性。