头孢他啶对大鼠的肾毒性。
Ceftazidime nephrotoxicity in rats.
作者信息
Luft F C, Visscher D W, Nierste D M, Blase D K, Walker N A, Aronoff G R
出版信息
Antimicrob Agents Chemother. 1984 Apr;25(4):513-4. doi: 10.1128/AAC.25.4.513.
Abstract
The nephrotoxicity of ceftazidime compared with that of cefazolin or cephaloridine and the capacity of ceftazidime to enhance the nephrotoxicity of tobramycin were evaluated in rats. Only cephaloridine and tobramycin given alone altered creatinine clearance or caused significant histological injury. Our data suggest that ceftazidime is no more nephrotoxic than cefazolin and does not enhance the nephrotoxicity of tobramycin.
摘要
在大鼠中评估了头孢他啶与头孢唑林或头孢噻啶相比的肾毒性，以及头孢他啶增强妥布霉素肾毒性的能力。仅单独给予头孢噻啶和妥布霉素会改变肌酐清除率或造成明显的组织学损伤。我们的数据表明，头孢他啶的肾毒性并不比头孢唑林更大，也不会增强妥布霉素的肾毒性。
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