在开发油质红酵母 ATCC 20509 作为定制微生物油脂的新型细胞工厂方面的机遇与挑战。
Opportunities and challenges in the development of Cutaneotrichosporon oleaginosus ATCC 20509 as a new cell factory for custom tailored microbial oils.
机构信息
Technische Universität München, Division of Industrial Biocatalysis, Lichtenbergstraße 4, 85748, Garching, Germany.
Westerdijk Institute, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.
出版信息
Microb Cell Fact. 2017 Oct 25;16(1):178. doi: 10.1186/s12934-017-0791-9.
Abstract
Cutaneotrichosporon oleaginosus ATCC 20509, previously known as Trichosporon oleaginosus, Cryptococcus curvatus, Apiotrichum curvatum or Candida curvata D is an oleaginous yeast with several favorable qualities: it is fast growing, accumulates high amounts of lipid and has a very broad substrate spectrum. Its resistance to hydrolysis byproducts and genetic accessibility make it a promising cell factory for custom tailored microbial oils. However, literature about this organism is of varying degree of quality. Moreover, due to numerous changes of the species name, reports are highly scattered and poorly cited. This led to a poor integration of the findings into a unified body of knowledge. Particularly, errors in strain name usage and consequently citation are found even in most recent literature. To simplify future work, this review provides an overview of published studies and main findings regarding the metabolic capacities of C. oleaginosus.
摘要
皮脂霉 ATCC 20509，以前称为油脂酵母、弯孢 cryptococcus、Apiotrichum 或 Candida curvata D，是一种产油酵母，具有多种优良特性：生长迅速、积累大量油脂、具有非常广泛的底物谱。它对水解副产物的抗性和遗传可及性使其成为定制微生物油脂的有前途的细胞工厂。然而，关于该生物体的文献质量参差不齐。此外，由于物种名称的多次更改，报告高度分散且引用不佳。这导致研究结果难以整合到一个统一的知识体系中。特别是，即使在最近的文献中，也发现了菌株名称使用和引用方面的错误。为了简化未来的工作，本综述提供了已发表的关于皮脂霉代谢能力的研究和主要发现的概述。
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