Fujita T, Fujimoto Y, Wada K, Kaneko M, Sakuma S, Iso T
Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan.
J Pharm Pharmacol. 1988 Sep;40(9):650-1. doi: 10.1111/j.2042-7158.1988.tb05329.x.
The effect of 2-mercaptopropionylglycine (tiopronin), which is widely used for the treatment of various hepatic disorders, on the generation of medullary prostaglandins (PG) E2 and F2 alpha has been examined. Tiopronin had a potent inhibitory effect on PG E2 formation. Simultaneously, PG F2 alpha production was increased. In the presence of tiopronin the net increased amount of PG F2 alpha was much smaller than the net decreased amount of PG E2 (6-20%). These results suggest that tiopronin has the potential to modulate PG E2 and F2 alpha synthesis by affecting endoperoxide E2 isomerase or endoperoxide reductase and that this effect may represent some pharmacological action of the drug.
已对广泛用于治疗各种肝脏疾病的2-巯基丙酰甘氨酸（硫普罗宁）对髓质前列腺素（PG）E2和F2α生成的影响进行了研究。硫普罗宁对PG E2的形成有强效抑制作用。同时，PG F2α的生成增加。在硫普罗宁存在的情况下，PG F2α的净增加量远小于PG E2的净减少量（6 - 20%）。这些结果表明，硫普罗宁可通过影响内过氧化物E2异构酶或内过氧化物还原酶来调节PG E2和F2α的合成，且这种作用可能代表了该药物的某些药理作用。
