Zilker T, Fogt F, von Clarmann M
Toxikologische Abteilung der II. Med. Klinik der Technischen Universität München.
Klin Wochenschr. 1988 Nov 15;66(22):1138-41. doi: 10.1007/BF01727849.
Paraquat structurally resembles N-methyl-4-phenyltetrahydropyridine (MPTP) and its metabolite 1-methyl-4-phenylpyridine (MPP+). MPTP and MPP+ are neurotoxic chemicals, which induce in exposed humans and in animal-models a Parkinson's disease. A high correlation between the incidence of Parkinson's disease and herbicide use in Canada led to the assumption that paraquat could give rise to parkinsonism. We have therefore carried out a follow-up study with patients having had dermal contact with paraquat or having swallowed paraquat accidentally or in a suicidal attempt. 7 patients took part in the study. Three of them had dermal contact. One had ingested paraquat by accident and three were survivors from suicidal paraquat intake. It was possible to exclude parkinsonism in all patients. One patient exhibited tardive dykinesia most likely due to a long term therapy with neuroleptic drugs.
百草枯在结构上类似于1-甲基-4-苯基四氢吡啶（MPTP）及其代谢产物1-甲基-4-苯基吡啶（MPP+）。MPTP和MPP+是神经毒性化学物质，可在接触者和动物模型中诱发帕金森病。加拿大帕金森病发病率与除草剂使用之间的高度相关性导致人们认为百草枯可能引发帕金森症。因此，我们对皮肤接触百草枯或意外吞食百草枯或自杀性服用百草枯的患者进行了一项随访研究。7名患者参与了该研究。其中3人有皮肤接触。1人意外摄入百草枯，3人是自杀性服用百草枯的幸存者。所有患者均排除帕金森症。1名患者表现出迟发性运动障碍，很可能是由于长期使用抗精神病药物治疗所致。
