分娩时明显的子宫炎症反应是哺乳动物的古老特征。
A pronounced uterine pro-inflammatory response at parturition is an ancient feature in mammals.
机构信息
Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA.
出版信息
Proc Biol Sci. 2017 Oct 25;284(1865). doi: 10.1098/rspb.2017.1694.
Regulating maternal immunity is necessary for successful human pregnancy. Whether this is needed in mammals with less invasive placentation is subject to debate. Indeed, the short gestation times in marsupials have been hypothesized to be due to a lack of immune regulation during pregnancy. Alternatively, the maternal marsupial immune system may be unstimulated in the absence of a highly invasive placenta. Transcripts encoding pro-inflammatory cytokines were found to be overrepresented in the whole uterine transcriptome at terminal pregnancy in the opossum, To investigate this further, immune gene transcripts were quantified throughout opossum gestation. Transcripts encoding pro-inflammatory cytokines remained relatively low during pre- and peri-attachment pregnancy stages. Levels dramatically increased late in gestation, peaking within 12 h prior to parturition. These results mirror the spike of inflammation seen at eutherian parturition but not at attachment or implantation. Our results are consistent with the role of pro-inflammatory cytokines at parturition being an ancient and conserved birth mechanism in therian mammals.
调节母体免疫是成功妊娠所必需的。对于胎盘侵入性较小的哺乳动物来说，这是否有必要还有待商榷。事实上，有假说认为，由于妊娠期间缺乏免疫调节，有袋动物的妊娠期较短。或者，在没有高度侵入性胎盘的情况下，母体有袋动物的免疫系统可能未被激活。在负鼠的终末妊娠中，发现编码促炎细胞因子的转录本在整个子宫转录组中过表达。在附着前和附着期妊娠阶段，编码促炎细胞因子的转录本相对较低。在妊娠后期水平急剧增加，在分娩前 12 小时达到峰值。这些结果反映了真兽类分娩时出现的炎症高峰，但在附着或植入时并未出现。我们的结果与促炎细胞因子在分娩时的作用一致，即在有胎盘哺乳动物中，它是一种古老而保守的分娩机制。
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