The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Molecules. 2018 Apr 4;23(4):826. doi: 10.3390/molecules23040826.
Chemotherapy has been widely applied in clinics. However, the therapeutic potential of chemotherapy against cancer is seriously dissatisfactory due to the nonspecific drug distribution, multidrug resistance (MDR) and the heterogeneity of cancer. Therefore, combinational therapy based on chemotherapy mediated by nanotechnology, has been the trend in clinical research at present, which can result in a remarkably increased therapeutic efficiency with few side effects to normal tissues. Moreover, to achieve the accurate pre-diagnosis and real-time monitoring for tumor, the research of nano-theranostics, which integrates diagnosis with treatment process, is a promising field in cancer treatment. In this review, the recent studies on combinational therapy based on chemotherapy will be systematically discussed. Furthermore, as a current trend in cancer treatment, advance in theranostic nanoparticles based on chemotherapy will be exemplified briefly. Finally, the present challenges and improvement tips will be presented in combination therapy and nano-theranostics.
化疗已广泛应用于临床。然而，由于药物分布不均匀、多药耐药性（MDR）和肿瘤异质性等原因，化疗对癌症的治疗潜力并不理想。因此，基于纳米技术介导的化疗联合治疗已成为目前临床研究的趋势，这种治疗方法可以显著提高治疗效率，同时对正常组织的副作用较小。此外，为了实现对肿瘤的精确预诊断和实时监测，将诊断与治疗过程相结合的纳米诊疗研究是癌症治疗的一个有前途的领域。在本文中，我们将对基于化疗的联合治疗的最新研究进行系统地讨论。此外，作为癌症治疗的当前趋势，我们将简要举例说明基于化疗的治疗诊断一体化纳米颗粒的最新进展。最后，我们将结合联合治疗和纳米诊疗提出目前的挑战和改进建议。
