Uehara Karina, Iwashita Hidehiko, Tanabe Yasuka, Kurima Kiyoto, Oshiro Mariko, Kina Shinichiro, Ota Atsuko, Iwashita Akinori, Kinjo Takao
Division of Morphological Pathology, Department of Basic Laboratory Sciences, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa903-0215, Japan.
Department of Internal Medicine, Iwashita Medical Clinic, Okinawa, 904-2214Japan.
Open Med (Wars). 2017 Oct 17;12:335-339. doi: 10.1515/med-2017-0048. eCollection 2017.
Esophageal xanthoma is a rare lesion which is an asymptomatic small yellowish polyp, and most of the reported cases were solitary lesion. Histologically, aggregations of foam cells are found under the papillary hypertrophic squamous epithelium and the foam cells express CD68. The etiology of esophageal xanthoma is unknown. The focal irritation of the esophageal mucosa and infiltrated inflammatory cells are presumed to contribute to its pathogenesis. Although the pathogenesis may be associated with inflammation, the type and nature of the macrophages remain unclear. Here we report a 46-year-old male with esophageal xanthoma, which was incidentally found by endoscopy. Histologically, acute inflammation was not noted, and immunohistochemistry revealed that the foam cells seen in this case of esophageal xanthoma expressed increased levels of M2 macrophage markers. These findings suggest that esophageal xanthoma is associated with late inflammatory and reparative processes long after the initial inflammation of esophageal squamous epithelium.
食管黄色瘤是一种罕见病变，表现为无症状的小的淡黄色息肉，且大多数报道病例为孤立性病变。组织学上，在乳头样肥厚的鳞状上皮下可见泡沫细胞聚集，且泡沫细胞表达CD68。食管黄色瘤的病因尚不清楚。推测食管黏膜的局灶性刺激和浸润的炎症细胞促成其发病机制。尽管发病机制可能与炎症有关，但巨噬细胞的类型和性质仍不清楚。在此，我们报告一例46岁男性食管黄色瘤患者，该病变在内镜检查时偶然发现。组织学上，未发现急性炎症，免疫组化显示该例食管黄色瘤中的泡沫细胞表达M2巨噬细胞标志物的水平升高。这些发现提示食管黄色瘤与食管鳞状上皮初始炎症很久之后的晚期炎症和修复过程有关。
