Zouari Hajer, Latiri Imed, Mahjoub Mohamed, Boussarsar Mohamed, Benzarti Mohamed, Abdelghani Ahmed, Ben Saad Helmi
1 Physiology Laboratory, Faculty of Medicine of Sousse, University of Sousse, Tunisia.
2 Department of Hospital Hygiene, Farhat HACHED University Hospital in Sousse, Tunisia.
Am J Mens Health. 2018 Mar;12(2):359-369. doi: 10.1177/1557988317734131. Epub 2017 Oct 26.
No previous study has raised the effects of RIF on lung function data of chronic obstructive pulmonary disease (COPD) patients. The objective of the present study was to assess the effects of RIF on spirometric data measured in male patients with a stable COPD. Sixteen patients with stable COPD (mean ± SD of age: 64 ± 7 years) who fasted during Ramadan volunteered to the study. Three sessions (Before-R, End-R, and After-R) were selected for spirometry tests that were consistently performed 2.5-4.5 hr before fasting break. Assessment sessions comprised: forced vital capacity (FVC), 1st s forced expiratory volume (FEV), FEV/FVC, peak expiratory flow (PEF), maximal mid-expiratory flow (MMEF), and forced expiratory flow rate at the x% of FVC to be exhaled (FEFx%). A reversibility test was performed only during the Before-Ramadan session. Spirometric data were expressed in percentages of local reference values. Findings were analyzed by applying repeated measures analysis of variance. The mean ± SD of the postbronchodilator FEV/FVC ratio and the FEV were, respectively, 0.52 ± 0.14 and 48 ± 19%. The mean ± SD of FEV (Before-R: 47 ± 19, End-R: 45 ± 18, After-R: 44 ± 19%), FVC (Before-R: 73 ± 18, End-R: 71 ± 16, After-R: 69 ± 17%), FEV/FVC (Before-R: 67 ± 16, End-R: 66 ± 16, After-R: 65 ± 16%), PEF (Before-R: 46 ± 19, End-R: 47 ± 22, After-R: 45 ± 21%), MMEF (Before-R: 19 ± 10, End-R: 18 ± 8, After-R: 18 ± 9%), FEF (Before-R: 16 ± 6, End-R: 16 ± 5, After-R: 15 ± 5%), FEF (Before-R: 21 ± 14, End-R: 20 ± 12, After-R: 20 ± 12%) and FEF (Before-R: 27 ± 19, End-R: 27 ± 19, After-R: 27 ± 19%) were not significantly influenced by RIF. RIF did not bring about any significant changes in the spirometric data of stable COPD male patients fasting the 2016 holy month of Ramadan.
此前尚无研究提及利福平对慢性阻塞性肺疾病（COPD）患者肺功能数据的影响。本研究的目的是评估利福平对稳定期男性COPD患者肺量计测量数据的影响。16例在斋月期间禁食的稳定期COPD患者（年龄均值±标准差：64±7岁）自愿参与本研究。选择三个时段（斋月前、斋月结束时、斋月后）进行肺量计测试，测试均在禁食结束前2.5 - 4.5小时进行。评估时段包括：用力肺活量（FVC）、第1秒用力呼气容积（FEV）、FEV/FVC、呼气峰值流速（PEF）、最大呼气中期流速（MMEF）以及呼出FVC的x%时的用力呼气流量（FEFx%）。仅在斋月前时段进行可逆性测试。肺量计数据以当地参考值的百分比表示。采用重复测量方差分析对结果进行分析。支气管扩张剂治疗后FEV/FVC比值和FEV的均值±标准差分别为0.52±0.14和48±19%。FEV（斋月前：47±19，斋月结束时：45±18，斋月后：44±19%）、FVC（斋月前：73±18，斋月结束时：71±16，斋月后：69±17%）、FEV/FVC（斋月前：67±16，斋月结束时：66±16，斋月后：65±16%）、PEF（斋月前：46±19，斋月结束时：47±22，斋月后：45±21%）、MMEF（斋月前：19±10，斋月结束时：18±8，斋月后：18±9%）、FEF（斋月前：16±6，斋月结束时：16±5，斋月后：15±5%）、FEF（斋月前：21±14，斋月结束时：20±12，斋月后：20±12%）和FEF（斋月前：27±19，斋月结束时：27±19，斋月后：27±19%）均未受到利福平的显著影响。在2016年斋月禁食的稳定期男性COPD患者中，利福平未导致肺量计数据发生任何显著变化。
