Ratajczak M Z
Department of Immunology CSK WAM, Warszawa.
Arch Immunol Ther Exp (Warsz). 1988;36(2):235-43.
About 25% mice treated for radiation-induced bone marrow aplasia with allogeneic transplantation of histoincompatible fetal liver cells survived four months. The same survival time was observed in 80% of mice after transplantation of syngeneic fetal liver cells. Mice irradiated and not treated and those receiving transplants of allogeneic histoincompatible bone marrow died within a few weeks after transplantation. This observation confirms the reports on the therapeutic superiority of transplantation of haemopoietic fetal liver cells over transplantation of bone marrow of similar tissue incompatibility and reports on the usefulness of tissue matching, if possible. Another observation was an absence of inactivation of the haemopoietic stem cells in mixtures of genotypically different fetal liver cells. The animals receiving these cell mixtures showed survival rates similar to those of the animals receiving genetically homogenous cells. This opens theoretical possibilities for undertaking clinical trials of transplantation of cells from several fetal livers, especially in view of the accumulating reports that one human fetal liver may be too small to serve as a source of stem cells for ensuring successful transplantation.
用组织不相容的胎肝细胞进行同种异体移植治疗辐射诱导的骨髓再生障碍，约25%的小鼠存活了四个月。在移植同基因胎肝细胞后，80%的小鼠观察到相同的存活时间。接受照射但未治疗的小鼠以及接受组织不相容的同种异体骨髓移植的小鼠在移植后几周内死亡。这一观察结果证实了关于造血胎肝细胞移植优于具有相似组织不相容性的骨髓移植的报道，以及关于组织配型（如果可能的话）有用性的报道。另一个观察结果是，基因不同的胎肝细胞混合物中的造血干细胞没有失活。接受这些细胞混合物的动物的存活率与接受基因同质细胞的动物相似。这为开展来自多个胎儿肝脏的细胞移植临床试验打开了理论可能性，特别是鉴于越来越多的报道称，一个人胎儿肝脏可能太小，无法作为确保成功移植的干细胞来源。
