Gulya E, Gábor Szabó L, Kelemen E
2nd Department of Internal Medicine, Central Hospital of Ministry of the Interior, Budapest, Hungary.
Haematologia (Budap). 1997;28(2):71-6.
The effect of very high haemopoietic cell doses were investigated on the composition of splenic cell colonies/clusters in irradiated animals under xenogeneic circumstances. Differential cluster/colony counts from serial histological sections of the spleen were investigated before, and 9-12 days after transplantation of fetal liver- or adult bone marrow-derived haemopoietic cells following 5.0 to 8.5 Gy total body irradiation. Syngeneic as well as xenogeneic (mouse to rat and rat to mouse) transplantations were carried out. Cluster/colony differentials changed with the increase of the injected cell mass from 10(5) to 10(6) and 10(7) or more, i.e. the overwhelming erythroid pattern became trilinear even with xenogeneic transplants.
研究了在异种环境下，极高剂量造血细胞对受辐照动物脾细胞集落/簇组成的影响。在全身照射5.0至8.5 Gy后，移植胎儿肝脏或成年骨髓来源的造血细胞之前以及移植后9至12天，对脾脏连续组织切片进行差异集落/簇计数。进行了同基因以及异种（小鼠到大鼠和大鼠到小鼠）移植。随着注射细胞量从10(5)增加到10(6)、10(7)或更多，集落/簇差异发生变化，即即使是异种移植，压倒性的红系模式也变为三系模式。
