Mensi Carolina, Mendola Marco, Dallari Barbara, Sokooti Maryam, Tabibi Ramin, Riboldi Luciano, Consonni Dario
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.
School of Occupational Medicine, Università degli Studi di Milano, Milan, Italy.
Cancer Epidemiol. 2017 Dec;51:68-73. doi: 10.1016/j.canep.2017.10.003. Epub 2017 Oct 23.
We examined characteristics of peritoneal (PEM) and pleural (PLM) mesothelioma in Lombardy, Italy.
From the Lombardy Mesothelioma Registry we selected PEM (N=300) and PLM (N=5011) cases diagnosed in 2000-2014. We investigated asbestos exposure and presence of asbestosis or pleural plaques.
Incidence rates (per 1,000,000 person-years, world standardized) of PEM were 1.2 (men) and 0.9 (women), compared with 22.6 and 8.4 for PLM. Asbestosis (both genders) and pleural plaques (men) were more frequent among PEM cases. Occupational asbestos exposure was similar in PEM and PLM cases. We found higher proportions of PEMs employed in the asbestos cement production.
The higher frequency of pleural plaques in PEM cases confirm the association between asbestos and peritoneal mesothelioma. The higher proportions of asbestosis and of past employment in the asbestos-cement sector among PEM cases suggest a possible role of high exposures to asbestos in the peritoneal mesothelioma genesis.
我们研究了意大利伦巴第地区腹膜间皮瘤（PEM）和胸膜间皮瘤（PLM）的特征。
从伦巴第间皮瘤登记处选取了2000 - 2014年诊断的PEM病例（N = 300）和PLM病例（N = 5011）。我们调查了石棉暴露情况以及石棉肺或胸膜斑的存在情况。
PEM的发病率（每100万人年，世界标准化）男性为1.2，女性为0.9，而PLM分别为22.6和8.4。石棉肺（男女均有）和胸膜斑（男性）在PEM病例中更为常见。PEM和PLM病例中的职业性石棉暴露情况相似。我们发现受雇于石棉水泥生产行业的PEM患者比例更高。
PEM病例中胸膜斑的高发生率证实了石棉与腹膜间皮瘤之间的关联。PEM病例中石棉肺以及过去受雇于石棉水泥行业的比例较高，这表明高剂量石棉暴露在腹膜间皮瘤发病过程中可能发挥了作用。
