Zanvyl Krieger Mind/Brain Institute, Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA.
Nat Neurosci. 2017 Oct 26;20(11):1493-1503. doi: 10.1038/nn.4657.
Distinct processing of objects and space has been an organizing principle for studying higher-level vision and medial temporal lobe memory. Here, however, we discuss how object and spatial information are in fact closely integrated in vision and memory. The ventral, object-processing visual pathway carries precise spatial information, transformed from retinotopic coordinates into relative dimensions. At the final stages of the ventral pathway, including the dorsal anterior temporal lobe (TEd), object-sensitive neurons are intermixed with neurons that process large-scale environmental space. TEd projects primarily to perirhinal cortex (PRC), which in turn projects to lateral entorhinal cortex (LEC). PRC and LEC also combine object and spatial information. For example, PRC and LEC neurons exhibit place fields that are evoked by landmark objects or the remembered locations of objects. Thus, spatial information, on both local and global scales, is deeply integrated into the ventral (temporal) object-processing pathway in vision and memory.
物体和空间的不同处理一直是研究更高层次视觉和内侧颞叶记忆的组织原则。然而，在这里，我们讨论的是实际上物体和空间信息是如何在视觉和记忆中紧密结合的。腹侧，物体处理的视觉通路携带精确的空间信息，从视网膜坐标转换为相对维度。在腹侧通路的最后阶段，包括背侧前颞叶（TEd），物体敏感神经元与处理大尺度环境空间的神经元混合在一起。TEd 主要投射到旁嗅皮层（PRC），而 PRC 又投射到外侧内嗅皮层（LEC）。PRC 和 LEC 也结合了物体和空间信息。例如，PRC 和 LEC 神经元表现出由地标物体或物体的记忆位置引发的位置场。因此，空间信息，无论是局部还是全局尺度，都深深地整合到了视觉和记忆中的腹侧（颞叶）物体处理通路中。
