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脂质代谢促进刺猬信号通路。

Lipid metabolism fattens up hedgehog signaling.

机构信息

The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.

Nuffield Department of Clinical Neurosciences (NDCN), Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK.

出版信息

BMC Biol. 2017 Oct 26;15(1):95. doi: 10.1186/s12915-017-0442-y.

DOI:10.1186/s12915-017-0442-y
PMID:29073896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5659038/
Abstract

Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic hedgehog. Hedgehog signaling is essential for development, proliferation, and stem cell maintenance, and it is a driver of certain cancers. Lipid metabolism has a profound influence on both hedgehog signal transduction and the properties of the ligands themselves, leading to changes in the strength of hedgehog signaling and cellular functions. Here we review the evolving understanding of the relationship between lipids and hedgehog signaling.

摘要

信号通路指导器官发生，通常通过对细胞的浓度依赖性影响来实现。Hedgehog 通路使细胞能够感知和响应 Hedgehog 配体，其中研究最充分的是 sonic Hedgehog。Hedgehog 信号对于发育、增殖和干细胞维持至关重要，也是某些癌症的驱动因素。脂代谢对 Hedgehog 信号转导和配体本身的特性都有深远的影响，导致 Hedgehog 信号的强度和细胞功能发生变化。在这里，我们回顾了对脂类与 Hedgehog 信号之间关系的不断发展的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf85/5659038/d463951a44b3/12915_2017_442_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf85/5659038/cab3841c3bf1/12915_2017_442_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf85/5659038/21c3060c136d/12915_2017_442_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf85/5659038/158e1147ccfb/12915_2017_442_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf85/5659038/1f4f63d09b74/12915_2017_442_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf85/5659038/d463951a44b3/12915_2017_442_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf85/5659038/cab3841c3bf1/12915_2017_442_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf85/5659038/21c3060c136d/12915_2017_442_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf85/5659038/158e1147ccfb/12915_2017_442_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf85/5659038/1f4f63d09b74/12915_2017_442_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf85/5659038/d463951a44b3/12915_2017_442_Fig5_HTML.jpg

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Lipid metabolism fattens up hedgehog signaling.

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本文引用的文献

[1]
Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.

Mol Cell. 2017-3-23

[2]
Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.

Elife. 2016-10-5

[3]
Cholesterol Biosynthesis: A Mechanistic Overview.

Biochemistry. 2016-10-4

[4]
Patched1 and Patched2 inhibit Smoothened non-cell autonomously.

Elife. 2016-8-23

[5]
Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.

Cell. 2016-8-25

[6]
Structural basis of Smoothened regulation by its extracellular domains.

Nature. 2016-7-28

[7]
Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection.

Cell. 2016-6-2

[8]
Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis.

Elife. 2016-5-17

[9]
Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols.

Proc Natl Acad Sci U S A. 2016-5-24

[10]
Drosophila Segment Polarity Mutants and the Rediscovery of the Hedgehog Pathway Genes.

Curr Top Dev Biol. 2016

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