The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Nuffield Department of Clinical Neurosciences (NDCN), Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK.
BMC Biol. 2017 Oct 26;15(1):95. doi: 10.1186/s12915-017-0442-y.
Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic hedgehog. Hedgehog signaling is essential for development, proliferation, and stem cell maintenance, and it is a driver of certain cancers. Lipid metabolism has a profound influence on both hedgehog signal transduction and the properties of the ligands themselves, leading to changes in the strength of hedgehog signaling and cellular functions. Here we review the evolving understanding of the relationship between lipids and hedgehog signaling.
信号通路指导器官发生，通常通过对细胞的浓度依赖性影响来实现。Hedgehog 通路使细胞能够感知和响应 Hedgehog 配体，其中研究最充分的是 sonic Hedgehog。Hedgehog 信号对于发育、增殖和干细胞维持至关重要，也是某些癌症的驱动因素。脂代谢对 Hedgehog 信号转导和配体本身的特性都有深远的影响，导致 Hedgehog 信号的强度和细胞功能发生变化。在这里，我们回顾了对脂类与 Hedgehog 信号之间关系的不断发展的认识。
