Ortiz A P, Romaguera J, Pérez C M, González D, Muñoz C, González L, Marrero E, Tortolero-Luna G, Suárez E, Palefsky J
Cancer Control and Population Sciences Program, Comprehensive Cancer Center, University of Puerto Rico, United States; Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, United States.
Department of OBGYN, School of Medicine, Medical Sciences Campus, University of Puerto Rico, United States.
Papillomavirus Res. 2016 Dec;2:89-96. doi: 10.1016/j.pvr.2016.04.002. Epub 2016 Apr 26.
Oncogenic HPV infection is associated to anogenital cancer. We estimate the prevalence and correlates of anogenital HPV infection among a population-based sample of women aged 16-64 years living in the metropolitan area of Puerto Rico.
564 women completed face-to-face and computer assisted interviews and self-collected anal and cervical specimens. HPV DNA testing used MY09/MY11 consensus HPV L1 primers and beta-globin as an internal control for sample amplification. Positive specimens were typed by dot-blot hybridization.
Weighted prevalence of cervical, anal, and cervical/anal co-infection was 29.4%, 38.6%, and 17.1%, respectively. The commonest oncogenic HPV types detected in the cervix and anus were: 68 (8% vs. 7%) and 16 (5.5% vs. 5.1%), correspondingly. Having ≥3 lifetime sexual partners (OR: 2.3; 95% CI: 1.5-3.5) and last year anal intercourse (OR: 1.6; 95% CI: 1.1-2.5) increased the odds of anogenital HPV infection. Cervical infection was independently associated to anal infection (OR: 3.0; 95% CI: 2.0-4.6).
Similar to others, our results confirm the burden of anogenital HPV infection in women and its relationship with sexual behavior. As vaccination increases, future studies should monitor changing trends in HPV infection in this population, and the relationship between anal and cervical HPV-related disease.
致癌性人乳头瘤病毒（HPV）感染与肛门生殖器癌有关。我们对居住在波多黎各 metropolitan 地区的 16 - 64 岁女性人群样本中肛门生殖器 HPV 感染的患病率及其相关因素进行了估计。
564 名女性完成了面对面和计算机辅助访谈，并自行采集了肛门和宫颈样本。HPV DNA 检测使用 MY09/MY11 共识 HPV L1 引物，并以β-珠蛋白作为样本扩增的内部对照。阳性样本通过点杂交进行分型。
宫颈、肛门和宫颈/肛门合并感染的加权患病率分别为 29.4%、38.6%和 17.1%。在宫颈和肛门中检测到的最常见致癌性 HPV 类型分别为：68（8%对 7%）和 16（5.5%对 5.1%）。有≥3 个性伴侣（比值比：2.3；95%置信区间：1.5 - 3.5）和去年有肛交行为（比值比：1.6；95%置信区间：1.1 - 2.5）会增加肛门生殖器 HPV 感染的几率。宫颈感染与肛门感染独立相关（比值比：3.0；95%置信区间：2.0 - 4.6）。
与其他研究结果相似，我们的结果证实了女性肛门生殖器 HPV 感染的负担及其与性行为的关系。随着疫苗接种率的提高，未来的研究应监测该人群中 HPV 感染的变化趋势，以及肛门和宫颈 HPV 相关疾病之间的关系。
