Department of Biostatistics and Epidemiology, Graduate School of Public Health, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
Department of Biology, Faculty of Natural Sciences, University of Puerto Rico, Río Piedras Campus, Puerto Rico.
P R Health Sci J. 2020 Mar;39(1):28-33.
There is a high prevalence of human papillomavirus (HPV) infection in Puerto Rico, but little is known about the prevalence of Chlamydia trachomatis (CT) infection in healthy Puerto Rican women. Thus we aimed to evaluate the seroprevalence and association and the association between HPV and CT.
This was a secondary data analysis from a cross-sectional, populationbased, study of HPV infection in women aged 16-64 years in Puerto Rico (2010-2013). Enzyme-linked immunosorbent assays (ELISA) were used to detect serum antibodies to CT and HPV. Logistic regression models were used to estimate the odds ratio (OR) for the association between HPV and CT serostatus.
The study included 524 women; mean age was 42 years. Overall, 97 (18.5%) women were CT-seropositive, 251 (47.0%) were HPV seropositive, and 57 (10.9%) had antibodies for both CT and HPV. Women who were CT-seropositive were more likely (p<0.05) to also be seropositive to any HPV type (ORadjusted: 1.7, IC 95% =1.1, 2.6), HPV 16/18 (ORadjusted: 1.6, IC 95% =1.0, 2.6) and HPV 6/11 (ORadjusted: 1.6, IC 95% =1.1, 2.6) than those CT-seronegative, after adjusting for possible confounding factors.
Given the association between CT and HPV seropositivity, longitudinal studies to evaluate whether CT infection influences HPV incidence and persistence in this group are warranted.
波多黎各的人乳头瘤病毒（HPV）感染率很高，但对健康波多黎各女性中沙眼衣原体（CT）感染的流行率知之甚少。因此，我们旨在评估 HPV 和 CT 的血清流行率和相关性以及它们之间的相关性。
这是对 HPV 在波多黎各年龄在 16-64 岁的女性中感染的一项横断面、基于人群的研究的二次数据分析（2010-2013 年）。酶联免疫吸附试验（ELISA）用于检测血清中针对 CT 和 HPV 的抗体。使用逻辑回归模型来估计 HPV 和 CT 血清阳性状态之间关联的优势比（OR）。
该研究纳入了 524 名女性；平均年龄为 42 岁。总体而言，97 名（18.5%）女性 CT 血清阳性，251 名（47.0%）HPV 血清阳性，57 名（10.9%）两种抗体均为阳性。CT 血清阳性的女性更有可能（p<0.05）对任何 HPV 类型（调整后的 OR：1.7，95%CI：1.1，2.6）、HPV 16/18（调整后的 OR：1.6，95%CI：1.0，2.6）和 HPV 6/11（调整后的 OR：1.6，95%CI：1.1，2.6）呈血清阳性，在调整了可能的混杂因素后。
鉴于 CT 和 HPV 血清阳性之间的相关性，需要进行纵向研究来评估 CT 感染是否会影响该人群中 HPV 的发病率和持续性。
