Improving individual predictions: Machine learning approaches for detecting and attacking heterogeneity in schizophrenia (and other psychiatric diseases).

Psychiatric diseases are very heterogeneous both in clinical manifestation and etiology. With the recent rise of using machine learning techniques to attempt to diagnose and prognose these disorders, the issue of heterogeneity becomes increasingly important. With the growing interest in personalized medicine, it becomes even more important to not only classify someone as a patient with a certain disorder, its treatment needs a more precise definition of the underlying neurobiology, since different biological origins of the same disease may require (very) different treatments. We review the possible contributions that machine learning techniques could make to explore the heterogeneous nature of psychiatric disorders with a focus on schizophrenia. First we will review how heterogeneity shows up and how machine learning, or multivariate pattern recognition methods in general, can be used to discover it. Secondly, we will discuss the possible uses of these techniques to attack heterogeneity, leading to improved predictions and understanding of the neurobiological background of the disorder.