Traub W H
Institut für Medizinische Mikrobiologie und Hygiene, Universität des Saarlandes, Homburg, BRD.
Chemotherapy. 1988;34(6):472-7. doi: 10.1159/000238611.
Five antimicrobial drugs (ciprofloxacin, clindamycin, imipenem, penicillin G, and rifampin) were examined for therapeutic efficacy in a murine model gas gangrene due to Clostridium perfringens type A, following infection with large bacterial inocula. Imipenem was effective against all 6 strains of C. perfringens; conversely, penicillin G failed against these 6 strains. Ciprofloxacin, clindamycin, and rifampin occupied intermediate positions.
对五种抗菌药物（环丙沙星、克林霉素、亚胺培南、青霉素G和利福平）进行了研究，以考察其在大剂量接种细菌导致的A型产气荚膜梭菌引起的小鼠气性坏疽模型中的治疗效果。亚胺培南对所有6株产气荚膜梭菌均有效；相反，青霉素G对这6株菌无效。环丙沙星、克林霉素和利福平处于中间位置。
