Institute of Clinical Microbiology, University of Szeged, Szeged, Hungary.
Infect Dis (Lond). 2020 Mar;52(3):196-201. doi: 10.1080/23744235.2019.1696472. Epub 2019 Nov 28.
and other gas gangrene-forming clostridia are commensals of the human gut and vaginal microbiota, but can cause serious or even fatal infections. As there are relatively few published studies on antibiotic susceptibility of these bacteria, we decided to perform a 10-year retrospective study in a South-Eastern Hungarian clinical centre. A total of 372 gas gangrene-forming spp. were isolated from clinically relevant samples and identified with rapid ID 32A (bioMérieux, France) and MALDI-TOF MS (Bruker Daltinics, Germany) methods. Antibiotic susceptibility was determined with E-tests. We identified 313 , 20 , 10 , 10 , 9 , 6 , 4 isolates. In isolates, the rate of penicillin resistance was 2.6% and the rate of clindamycin resistance 3.8%. Penicillin resistance was found in 6.8% and clindamycin resistance in 8.5% of the non-perfringens spp. isolates. The antibiotic susceptibility of isolates was in good agreement with previous publications. The rates of resistance to penicillin and clindamycin were very low. The resistance rates of non-perfringens spp. isolates were higher than those of strains, but lower than those published in the literature.
和其他气性坏疽形成梭菌是人类肠道和阴道微生物群的共生菌，但它们也可能导致严重甚至致命的感染。由于关于这些细菌的抗生素敏感性的研究相对较少，我们决定在东南匈牙利的一个临床中心进行一项为期 10 年的回顾性研究。总共从临床相关样本中分离出 372 株气性坏疽形成梭菌，并使用快速 ID 32A（生物梅里埃，法国）和 MALDI-TOF MS（布鲁克·道尔顿，德国）方法进行鉴定。采用 E 试验法测定抗生素敏感性。我们鉴定出 313 株、20 株、10 株、10 株、9 株、6 株、4 株。在 株中，青霉素耐药率为 2.6%，克林霉素耐药率为 3.8%。非产气荚膜梭菌 株的青霉素耐药率为 6.8%，克林霉素耐药率为 8.5%。 株的抗生素敏感性与之前的出版物一致。青霉素和克林霉素的耐药率非常低。非产气荚膜梭菌 株的耐药率高于 株，但低于文献报道的耐药率。
