Wong Lin Ho, Tan Endean
University College Cork, Cork, Ireland.
Tan Tock Seng Hospital, Singapore.
Int Med Case Rep J. 2017 Oct 13;10:341-344. doi: 10.2147/IMCRJ.S147779. eCollection 2017.
Oculogyric crisis (OGC), frequently caused by medications such as antiemetics, antidepressants, and anti-epileptics, is an acute dystonic reaction of the ocular muscles. It consists of wide-staring gaze (lasting variably from seconds to minutes), seizures, and a widely-opened mouth. To date, there have been no reports of anti-tuberculosis medications such as rifampicin, isoniazid, pyrazinamide or ethambutol inducing OGC. It is of utmost importance to recognize this adverse reaction, which could be incorrectly diagnosed as an anaphylactic-like reaction. In this paper, we highlight a case of a 66-year-old Indian man who presented with OGC induced by anti-tuberculosis medications which was initially suspected to be an anaphylactic reaction and was subsequently halted with the administration of diphenhydramine.
动眼危象（OGC）常由止吐药、抗抑郁药和抗癫痫药等药物引起，是眼肌的一种急性肌张力障碍反应。它表现为凝视（持续时间从数秒到数分钟不等）、惊厥和嘴巴大张。迄今为止，尚无关于利福平、异烟肼、吡嗪酰胺或乙胺丁醇等抗结核药物诱发动眼危象的报道。认识到这种可能被误诊为类过敏反应的不良反应至关重要。在本文中，我们重点介绍了一名66岁的印度男性病例，他因抗结核药物诱发动眼危象，最初被怀疑是过敏反应，随后通过给予苯海拉明而缓解。
