• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

免疫重建炎症综合征与巨细胞病毒肺炎病例报告：分类标准与标准化治疗中的要点及缺失环节

Immune Reconstitution Inflammatory Syndrome and Cytomegalovirus Pneumonia Case Report: Highlights and Missing Links in Classification Criteria and Standardized Treatment.

作者信息

Petarra-Del Río Stefania, Rodriguez-Hernandez Adrian, Anguiano-Landa Luis, Aguilar-Portillo Georgina, Zavala-Trujillo Isidro, Nava-Zavala Arnulfo Hernan, Zavala-Cerna Maria G

机构信息

Immunology Research Laboratory, International Program of Medicine, Universidad Autonoma de Guadalajara, Zapopan, JAL, Mexico.

Infectious Disease Department, Hospital Dr. Angel Leaño, Universidad Autonoma de Guadalajara, Zapopan, JAL, Mexico.

出版信息

Case Rep Infect Dis. 2017;2017:9314580. doi: 10.1155/2017/9314580. Epub 2017 Sep 18.

DOI:10.1155/2017/9314580
PMID:29075540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5624155/
Abstract

BACKGROUND

Cytomegalovirus (CMV) pulmonary involvement is rarely associated with IRIS; therefore, limited information is available.

CASE PRESENTATION

Here, we describe the case of a 43-year-old HIV-infected male who developed an unusual case of IRIS after cytomegalovirus (CMV) pneumonia. Clinically there was a progressive and paradoxical worsening of respiratory distress, despite being treated for CMV after initiation with antiretroviral therapy. Chest X-ray revealed disseminated infiltrates in both lungs; chest CT-scan showed generalized lung involvement and mediastinal adenopathy. Pulmonary biopsy confirmed CMV pneumonia with the observation of typical viral inclusions on pneumocytes.

CONCLUSIONS

CMV pneumonia can be associated with the development of IRIS requiring treatment with immunosuppressant's and immunomodulatory drugs.

摘要

背景

巨细胞病毒（CMV）肺部受累很少与免疫重建炎症综合征（IRIS）相关；因此，可用信息有限。

病例报告

在此，我们描述了一名43岁感染HIV的男性病例，该患者在巨细胞病毒（CMV）肺炎后发生了罕见的免疫重建炎症综合征（IRIS）。临床上，尽管在开始抗逆转录病毒治疗后对CMV进行了治疗，但呼吸窘迫仍进行性且反常地加重。胸部X线显示双肺弥漫性浸润；胸部CT扫描显示全肺受累及纵隔淋巴结肿大。肺活检证实为CMV肺炎，在肺细胞上观察到典型的病毒包涵体。

结论

CMV肺炎可能与免疫重建炎症综合征（IRIS）的发生有关，需要使用免疫抑制剂和免疫调节药物进行治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b55/5624155/88a00411f056/CRIID2017-9314580.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b55/5624155/8113d9d59931/CRIID2017-9314580.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b55/5624155/e4ab25d04921/CRIID2017-9314580.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b55/5624155/88a00411f056/CRIID2017-9314580.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b55/5624155/8113d9d59931/CRIID2017-9314580.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b55/5624155/e4ab25d04921/CRIID2017-9314580.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b55/5624155/88a00411f056/CRIID2017-9314580.003.jpg

相似文献

1
Immune Reconstitution Inflammatory Syndrome and Cytomegalovirus Pneumonia Case Report: Highlights and Missing Links in Classification Criteria and Standardized Treatment.免疫重建炎症综合征与巨细胞病毒肺炎病例报告：分类标准与标准化治疗中的要点及缺失环节
Case Rep Infect Dis. 2017;2017:9314580. doi: 10.1155/2017/9314580. Epub 2017 Sep 18.
2
Proposed clinical case definition for cytomegalovirus-immune recovery retinitis.巨细胞病毒免疫恢复性视网膜炎的拟议临床病例定义。
Clin Infect Dis. 2014 Jul 15;59(2):298-303. doi: 10.1093/cid/ciu291. Epub 2014 Apr 24.
3
Recurrent cytomegalovirus colitis: a rare case of immune reconstitution inflammatory syndrome.复发性巨细胞病毒性结肠炎：一例罕见的免疫重建炎症综合征病例。
BMJ Case Rep. 2018 Jan 4;2018:bcr-2017-221121. doi: 10.1136/bcr-2017-221121.
4
A Rare Case of Cytomegalovirus Colitis with Subsequent Non-tubercular Mycobacteria Immune Reconstitution Inflammatory Syndrome.巨细胞病毒性结肠炎合并随后发生的非结核分枝杆菌免疫重建炎症综合征1例罕见病例
Middle East J Dig Dis. 2023 Jan;15(1):63-65. doi: 10.34172/mejdd.2023.323. Epub 2023 Jan 30.
5
Immune reconstitution inflammatory syndrome due to Mycobacterium avium complex successfully followed up using 18 F-fluorodeoxyglucose positron emission tomography-computed tomography in a patient with human immunodeficiency virus infection: A case report.18F-氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描成功随访一例人类免疫缺陷病毒感染患者因鸟分枝杆菌复合群引起的免疫重建炎症综合征：病例报告
BMC Med Imaging. 2015 Jul 18;15:24. doi: 10.1186/s12880-015-0063-2.
6
Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome in children.儿童结核相关的矛盾性免疫重建炎症综合征
Pediatr Pulmonol. 2016 Feb;51(2):157-64. doi: 10.1002/ppul.23221. Epub 2015 Jun 14.
7
Rhodoccocus Equi Pneumonia and Paradoxical Immune Reconstitution Inflammatory Syndrome in a Patient with Acquired Immune Deficiency Syndrome (AIDS).一名获得性免疫缺陷综合征（艾滋病）患者的马红球菌肺炎与矛盾性免疫重建炎症综合征
Am J Case Rep. 2017 Jan 19;18:67-71. doi: 10.12659/ajcr.900901.
8
Cytomegalovirus pneumonitis as an initial presentation in an HIV-infected patient.巨细胞病毒性肺炎作为一名HIV感染患者的首发表现。
Conn Med. 1999 Oct;63(10):585-8.
9
Multiorgan involvement due to cytomegalovirus infection in AIDS.
Braz J Infect Dis. 2007 Feb;11(1):176-8. doi: 10.1590/s1413-86702007000100039.
10
[Cytomegalovirus pneumonia treated with ganciclovir and intravenous CMV-hyperimmune globulin: case report].[更昔洛韦联合静脉注射巨细胞病毒超免疫球蛋白治疗巨细胞病毒肺炎：病例报告]
Kansenshogaku Zasshi. 1992 Oct;66(10):1488-91. doi: 10.11150/kansenshogakuzasshi1970.66.1488.

引用本文的文献

1
Co-infection with coronavirus disease 2019, previously undiagnosed human immunodeficiency virus, pneumonia and cytomegalovirus pneumonitis, with possible immune reconstitution inflammatory syndrome.2019冠状病毒病合并既往未诊断的人类免疫缺陷病毒感染、肺炎和巨细胞病毒性肺炎，可能伴有免疫重建炎症综合征。
IDCases. 2021;24:e01153. doi: 10.1016/j.idcr.2021.e01153. Epub 2021 May 7.
2
Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV.与HIV感染者免疫重建炎症综合征相关的全身炎症
Life (Basel). 2021 Jan 18;11(1):65. doi: 10.3390/life11010065.

本文引用的文献

1
Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2016 Recommendations of the International Antiviral Society-USA Panel.《成人HIV感染治疗和预防用抗逆转录病毒药物：美国国际抗病毒学会专家组2016年建议》
JAMA. 2016 Jul 12;316(2):191-210. doi: 10.1001/jama.2016.8900.
2
Treatment guidelines and prognosis of immune reconstitution inflammatory syndrome patients: a review.免疫重建炎症综合征患者的治疗指南与预后：综述
J Int Oral Health. 2015 Apr;7(4):92-5.
3
How understanding immunology contributes to managing CMV disease in immunosuppressed patients: now and in future.
了解免疫学如何有助于管理免疫抑制患者的巨细胞病毒疾病：现在及未来。
Med Microbiol Immunol. 2015 Jun;204(3):307-16. doi: 10.1007/s00430-015-0415-0. Epub 2015 Apr 21.
4
Immune reconstitution inflammatory syndrome in HIV-infected patients.HIV感染患者的免疫重建炎症综合征
HIV AIDS (Auckl). 2015 Feb 12;7:49-64. doi: 10.2147/HIV.S42328. eCollection 2015.
5
The pathogenesis of human cytomegalovirus.人类巨细胞病毒的发病机制。
J Pathol. 2015 Jan;235(2):288-97. doi: 10.1002/path.4437.
6
Immune recovery uveitis: pathogenesis, clinical symptoms, and treatment.免疫恢复性葡萄膜炎：发病机制、临床症状及治疗
Mediators Inflamm. 2014;2014:971417. doi: 10.1155/2014/971417. Epub 2014 Jun 24.
7
Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis.隐球菌性脑膜炎确诊后开始抗反转录病毒治疗的时机。
N Engl J Med. 2014 Jun 26;370(26):2487-98. doi: 10.1056/NEJMoa1312884.
8
Cytomegalovirus pneumonia in hematopoietic stem cell recipients.造血干细胞受体中的巨细胞病毒肺炎
J Intensive Care Med. 2014 Jul-Aug;29(4):200-12. doi: 10.1177/0885066613476454. Epub 2013 Feb 6.
9
Other HIV-associated pneumonias.其他与 HIV 相关的肺炎。
Clin Chest Med. 2013 Jun;34(2):243-54. doi: 10.1016/j.ccm.2013.01.007. Epub 2013 Apr 8.
10
Cytomegalovirus pneumonia in immunocompetent host: case report and literature review.免疫功能正常宿主巨细胞病毒肺炎：病例报告及文献复习。
J Clin Virol. 2012 Dec;55(4):356-9. doi: 10.1016/j.jcv.2012.08.010. Epub 2012 Sep 10.