Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Jiangxi Normal University, Nanchang, China.
Institute of Physical Education, Jiangxi Normal University, Nanchang, China.
Biomed Res Int. 2017;2017:2984826. doi: 10.1155/2017/2984826. Epub 2017 Sep 18.
Some reports have shown that nicotinamide N-methyltransferase (NNMT) is associated with the body mass index (BMI) and energy metabolism. Here we explored the association between gene polymorphisms and obesity. The subjects were recruited from male Chinese Han college student. 289 of them (19 ≤ body fat percentage (BF%)) were selected as the high body fat group (HBFG), 494 of them (3 ≤ BF% < 13.5) were selected as the low body fat group (LBFG), and then a case-control study (fat versus thin) was carried out to explore the association between the gene polymorphism and the body composition using tagSNPs method. A tagSNP (rs10891644) in gene was found significantly associated with the body composition ( < 0.0026). At this locus, the BF% for the genotype GT, TT, and GG were 14.56 ± 8.35, 13.47 ± 8.11, and 12.42 ± 7.50, respectively, and the differences between the GT and the GG + TT were highly significant ( < 0.01); the OR value of the GT versus (GG + TT) was 1.716 ( = 0.002, 95% CI = 1.240-2.235). Therefore, the variation of the tagSNP, rs10891644, is significantly associated with obesity and the GT carriers are the susceptible population.
一些报告表明，烟酰胺 N-甲基转移酶（NNMT）与体重指数（BMI）和能量代谢有关。在这里，我们探讨了基因多态性与肥胖之间的关系。研究对象是来自汉族男性大学生的志愿者。其中 289 人（19%≤体脂肪百分比（BF%））被选为高体脂肪组（HBFG），494 人（3%≤BF%<13.5）被选为低体脂肪组（LBFG），然后进行病例对照研究（胖与瘦），采用标签 SNP 法探讨基因多态性与身体成分的关系。在基因中发现了一个标签 SNP（rs10891644）与身体成分显著相关（<0.0026）。在这个位点，基因型 GT、TT 和 GG 的 BF%分别为 14.56±8.35、13.47±8.11 和 12.42±7.50，GT 基因型与 GG+TT 基因型之间的差异具有高度显著性（<0.01）；GT 与（GG+TT）的比值比（OR）为 1.716（=0.002，95%CI=1.240-2.235）。因此，标签 SNP rs10891644 的变异与肥胖显著相关，GT 携带者是易感人群。
