Van Hoogdalem E J, Geerts J A, De Boer A G, Breimer D D
Division of Pharmacology, Sylvius Laboratories, State University of Leiden, The Netherlands.
J Pharm Pharmacol. 1988 Nov;40(11):815-7. doi: 10.1111/j.2042-7158.1988.tb05181.x.
A study has been made to identify the component(s) responsible for the absorption-promoting effect of MGK medium chain glyceride preparation commercially available as a mixture of glyceryl-1-monooctanoate, glyceryl-1,3-dioctanoate, glyceryl-1,2-dioctanoate, glyceryl trioctanoate, octanoic acid and glycerol. The action of the individual constituents has been evaluated on the rectal absorption of cefazolin in conscious rats. The results indicate that the action of MGK can be completely explained by the effect of glyceryl-1-monooctanoate, which both enhanced the extent and rate of cefazolin uptake.
已有一项研究旨在确定市售MGK中链甘油酯制剂中负责吸收促进作用的成分，该制剂为甘油-1-单辛酸酯、甘油-1,3-二辛酸酯、甘油-1,2-二辛酸酯、三辛酸甘油酯、辛酸和甘油的混合物。已评估了各成分对清醒大鼠中头孢唑林直肠吸收的作用。结果表明，MGK的作用可完全由甘油-1-单辛酸酯的作用来解释，其既提高了头孢唑林摄取的程度又加快了摄取速率。
