Garrity Sean T, Iafe Nicholas A, Phasukkijwatana Nopasak, Chen Xuejing, Sarraf David
Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States.
Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5548-5555. doi: 10.1167/iovs.17-22036.
To identify and quantify the three distinct retinal capillary plexuses and the foveal avascular zone (FAZ) in healthy subjects according to age using optical coherence tomography angiography (OCTA) with novel projection artifact removal (PAR) software and improved segmentation.
All eyes in this cross-sectional study underwent OCTA imaging using RTVue XR Avanti with novel PAR AngioVue software. OCTA scans were analyzed and the three main parafoveal retinal capillary plexuses were segmented and vessel density and FAZ area were calculated.
A total of 152 normal eyes from 95 subjects (39 males, 56 females, mean age 42 ± 25 years) were included. The mean vessel density was 15.48 ± 2.04 mm-1 in the superficial retinal capillary plexus (SCP), 15.28 ± 1.82 mm-1 in the intermediate retinal capillary plexus (ICP), and 16.33 ± 2.32 mm-1 in the deep retinal capillary plexus (DCP) for 3 × 3-mm OCTA images. Analysis of 3 × 3-mm scans yielded a mean FAZ area of 0.270 ± 0.101 mm2. The average reduction in vessel density per year of age with 3 × 3-mm OCTA scans was 0.04 mm-1 (0.22%) in the SCP, 0.05 mm-1 (0.27%) in the ICP, and 0.06 mm-1 (0.30%) in the DCP. The average increase in FAZ area per year of age was 0.0015 mm2 (0.72%).
Novel PAR software may provide improved visualization of all three major parafoveal retinal capillary plexuses including the ICP. Using this technology, SCP, ICP, and DCP vessel density decreased with increasing age while FAZ area increased with age.
使用具有新型投影伪影去除（PAR）软件和改进分割功能的光学相干断层扫描血管造影（OCTA），根据年龄识别并量化健康受试者眼中三个不同的视网膜毛细血管丛以及黄斑无血管区（FAZ）。
在这项横断面研究中，所有眼睛均使用配备新型PAR AngioVue软件的RTVue XR Avanti进行OCTA成像。对OCTA扫描结果进行分析，分割出三个主要的黄斑旁视网膜毛细血管丛，并计算血管密度和FAZ面积。
共纳入95名受试者（39名男性，56名女性，平均年龄42±25岁）的152只正常眼睛。对于3×3毫米的OCTA图像，浅表视网膜毛细血管丛（SCP）的平均血管密度为15.48±2.04毫米-1，中间视网膜毛细血管丛（ICP）为15.28±1.82毫米-1，深部视网膜毛细血管丛（DCP）为16.33±2.32毫米-1。对3×3毫米扫描图像的分析得出，平均FAZ面积为0.270±0.101平方毫米。使用3×3毫米OCTA扫描，SCP中血管密度每年平均降低0.04毫米-1（即0.22%），ICP中为0.05毫米-1（即0.27%），DCP中为0.06毫米-1（即0.30%）。FAZ面积每年平均增加0.0015平方毫米（即0.72%）。
新型PAR软件可能会改善包括ICP在内的所有三个主要黄斑旁视网膜毛细血管丛的可视化效果。使用该技术时，SCP、ICP和DCP的血管密度随年龄增长而降低，而FAZ面积随年龄增长而增加。
