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使用光学相干断层扫描血管造影术对口腔微血管进行定量评估。

Quantitative assessment of the oral microvasculature using optical coherence tomography angiography.

作者信息

Zhang Tianyu, Zhang Yilong, Liao Jinpeng, Shepherd Simon, Huang Zhihong, Macluskey Michaelina, Li Chunhui

机构信息

Centre for Medical Engineering and Technology (CMET), School of Science and Engineering, University of Dundee, Dundee, United Kingdom.

Healthcare Engineering, School of Physics and Engineering Technology, University of York, York, United Kingdom.

出版信息

Front Bioeng Biotechnol. 2024 Sep 20;12:1464562. doi: 10.3389/fbioe.2024.1464562. eCollection 2024.

DOI:10.3389/fbioe.2024.1464562
PMID:39372434
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11449849/
Abstract

INTRODUCTION

Early diagnosis of oral squamous cell carcinoma can greatly improve treatment success rate and patient survival. Although Optical Coherence Tomography (OCT) based Angiography (OCTA) is a promising in vivo technique in oral imaging, there is a need for objective assessment of oral microvasculature.

METHODS

This study aimed to demonstrate a comprehensive methodology of quantitative assessing OCTA intraoral scanning results to provide measurable, reproducible data and to avoid subjective visual interpretations. Data were collected from 37 healthy subjects in total across four intraoral sites-buccal mucosa (n = 32), labial mucosa (n = 24), floor of the mouth (n = 13), and hard palate (n = 8)-using a non-invasive swept-source OCT system. Four quantitative metrics-vessel area density, vessel skeleton density, vessel diameter index, and a newly proposed weighted Tortuosity Index-were used to assess OCTA images in oral applications.

RESULTS

The quadruple quantitative assessment's repeatability was evaluated to be reliable. Analysis of a benign ulcer case revealed differences in these metrics compared to healthy cases.

DISCUSSION/CONCLUSION: In conclusion, we demonstrated a comprehensive method to quantify microvasculature in the oral cavity, showing considerable promise for early diagnosis and clinical management of oral diseases.

摘要

引言

口腔鳞状细胞癌的早期诊断可显著提高治疗成功率和患者生存率。尽管基于光学相干断层扫描（OCT）的血管造影术（OCTA）在口腔成像中是一种很有前景的体内技术，但仍需要对口腔微血管进行客观评估。

方法

本研究旨在展示一种全面的方法，用于定量评估OCTA口腔内扫描结果，以提供可测量、可重复的数据，并避免主观视觉解读。使用非侵入性扫频源OCT系统，从37名健康受试者的四个口腔部位——颊黏膜（n = 32）、唇黏膜（n = 24）、口底（n = 13）和硬腭（n = 8）——总共收集了数据。使用四个定量指标——血管面积密度、血管骨架密度、血管直径指数和新提出的加权迂曲指数——来评估口腔应用中的OCTA图像。

结果

四重定量评估的可重复性经评估是可靠的。对一例良性溃疡病例的分析显示，与健康病例相比，这些指标存在差异。

讨论/结论：总之，我们展示了一种量化口腔微血管的综合方法，在口腔疾病的早期诊断和临床管理方面显示出巨大潜力。

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Quantifying Microvascular Structure in Healthy and Infarcted Rat Hearts Using Optical Coherence Tomography Angiography.使用光相干断层扫描血管造影术定量分析健康和梗死大鼠心脏的微血管结构。
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Assessing Machine Learning Models for Predicting Age with Intracranial Vessel Tortuosity and Thickness Information.
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