Dadzie Albert K, Le David, Abtahi Mansour, Ebrahimi Behrouz, Adejumo Tobiloba, Son Taeyoon, Heiferman Michael J, Lim Jennifer I, Yao Xincheng
Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL 60607, USA.
Department of Ophthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL 60612, USA.
Biomed Opt Express. 2024 Sep 25;15(10):6010-6023. doi: 10.1364/BOE.537727. eCollection 2024 Oct 1.
Optical coherence tomography angiography (OCTA) has significantly advanced the study and diagnosis of eye diseases. However, current clinical OCTA systems and software tools lack comprehensive quantitative analysis capabilities, limiting their full clinical utility. This paper introduces the OCTA Retinal Vessel Analyzer (OCTA-ReVA), a versatile open-source platform featuring a user-friendly graphical interface designed for the automated extraction and quantitative analysis of OCTA features. OCTA-ReVA includes traditional established OCTA features based on binary vascular image processing, such as blood vessel density (BVD), foveal avascular zone area (FAZ-A), blood vessel tortuosity (BVT), and blood vessel caliber (BVC). Additionally, it introduces new features based on blood perfusion intensity processing, such as perfusion intensity density (PID), vessel area flux (VAF), and normalized blood flow index (NBFI), which provide deeper insights into retinal perfusion conditions. These additional capabilities are crucial for the early detection and monitoring of retinal diseases. OCTA-ReVA demystifies the intricate task of retinal vasculature quantification, offering a robust tool for researchers and clinicians to objectively evaluate eye diseases and enhance the precision of retinal health assessments.
光学相干断层扫描血管造影（OCTA）显著推动了眼科疾病的研究与诊断。然而，当前临床OCTA系统及软件工具缺乏全面的定量分析能力，限制了它们的临床应用价值。本文介绍了OCTA视网膜血管分析仪（OCTA-ReVA），这是一个多功能开源平台，具有用户友好的图形界面，旨在自动提取和定量分析OCTA特征。OCTA-ReVA包括基于二值血管图像处理的传统OCTA特征，如血管密度（BVD）、黄斑无血管区面积（FAZ-A）、血管迂曲度（BVT）和血管管径（BVC）。此外，它还引入了基于血流灌注强度处理的新特征，如灌注强度密度（PID）、血管面积通量（VAF）和归一化血流指数（NBFI），这些特征能更深入地了解视网膜灌注情况。这些额外功能对于视网膜疾病的早期检测和监测至关重要。OCTA-ReVA使复杂的视网膜血管系统量化任务变得清晰易懂，为研究人员和临床医生提供了一个强大的工具，用于客观评估眼科疾病并提高视网膜健康评估的准确性。
