转录和 RNA 调控 DNA 断裂修复。
Regulation of DNA break repair by transcription and RNA.
机构信息
Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02129, USA.
University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
出版信息
Sci China Life Sci. 2017 Oct;60(10):1081-1086. doi: 10.1007/s11427-017-9164-1. Epub 2017 Oct 24.
Abstract
Repair of DNA double-strand breaks (DSBs) via the homologous recombination (HR) pathway is a highly regulated process. A number of proteins that participate in HR are intricately modulated by the cell cycle and chromatin environments of DSBs. Recent studies have revealed a clear impact of transcription on HR in transcribed regions of the genome. Several models have been put forth to explain how the process of transcription and/or its RNA products may influence HR. Here we discuss the results and models from these studies, presenting an emerging view of transcription-coupled DSB repair.
摘要
通过同源重组（HR）途径修复 DNA 双链断裂（DSBs）是一个高度调控的过程。许多参与 HR 的蛋白质受到细胞周期和 DSB 染色质环境的精细调节。最近的研究揭示了转录对基因组转录区域 HR 的明显影响。已经提出了几种模型来解释转录过程及其 RNA 产物如何影响 HR。在这里，我们讨论了这些研究的结果和模型，提出了一个新兴的转录偶联 DSB 修复观点。
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