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与创伤性脑损伤患者预后相关的生物标志物

Biomarkers Associated with the Outcome of Traumatic Brain Injury Patients.

作者信息

Lorente Leonardo

机构信息

Intensive Care Unit, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife 38320, Spain.

出版信息

Brain Sci. 2017 Oct 27;7(11):142. doi: 10.3390/brainsci7110142.

DOI:10.3390/brainsci7110142
PMID:29076989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5704149/
Abstract

This review focuses on biomarkers associated with the outcome of traumatic brain injury (TBI) patients, such as caspase-3; total antioxidant capacity; melatonin; S100B protein; glial fibrillary acidic protein (GFAP); glutamate; lactate; brain-derived neurotrophic factor (BDNF); substance P; neuron-specific enolase (NSE); ubiquitin carboxy-terminal hydrolase L-1 (UCH-L1); tau; decanoic acid; and octanoic acid.

摘要

本综述聚焦于与创伤性脑损伤（TBI）患者预后相关的生物标志物，如半胱天冬酶-3；总抗氧化能力；褪黑素；S100B蛋白；胶质纤维酸性蛋白（GFAP）；谷氨酸；乳酸；脑源性神经营养因子（BDNF）；P物质；神经元特异性烯醇化酶（NSE）；泛素羧基末端水解酶L-1（UCH-L1）；tau蛋白；癸酸；以及辛酸。

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2
S100 B: A new concept in neurocritical care.S100B：神经重症监护中的一个新概念。
Iran J Neurol. 2017 Apr 4;16(2):83-89.
3
Serum melatonin levels in survivor and non-survivor patients with traumatic brain injury.创伤性脑损伤幸存者和非幸存者患者的血清褪黑素水平。
BMC Neurol. 2017 Jul 19;17(1):138. doi: 10.1186/s12883-017-0922-2.
4
Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain Injury Dynamics: A Systematic Review.用于监测人类创伤性脑损伤动态的血清蛋白生物标志物的系列采样：一项系统综述。
Front Neurol. 2017 Jul 3;8:300. doi: 10.3389/fneur.2017.00300. eCollection 2017.
5
The Role of Substance P in Secondary Pathophysiology after Traumatic Brain Injury.P物质在创伤性脑损伤后继发性病理生理学中的作用
Front Neurol. 2017 Jun 28;8:304. doi: 10.3389/fneur.2017.00304. eCollection 2017.
6
Elevated glutamate and lactate predict brain death after severe head trauma.谷氨酸和乳酸水平升高可预测严重颅脑创伤后的脑死亡。
Ann Clin Transl Neurol. 2017 May 4;4(6):392-402. doi: 10.1002/acn3.416. eCollection 2017 Jun.
7
Prognostic value of total antioxidant capacity to predict functional outcome in traumatic brain injury patients.总抗氧化能力对预测创伤性脑损伤患者功能结局的预后价值。
Clin Chem Lab Med. 2017 Oct 26;55(11):e265-e267. doi: 10.1515/cclm-2017-0022.
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