Laboratory of Dermatological Physiology, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama 350-0295, Japan.
Nutrients. 2017 Oct 27;9(11):1178. doi: 10.3390/nu9111178.
Purified glucosylceramide from beet extract (beet GlcCer) and beet extract containing an equal amount of GlcCer were administered orally to ultra violet B (UVB)-irradiated mice, and differences in the protective effects against skin barrier dysfunction caused by UVB irradiation were compared. In the beet GlcCer group, epidermal thickening and the decrease in stratum corneum (SC) ceramide content caused by UVB irradiation were reduced. In the group that was orally administered beet extract containing glucosylceramide, effects similar to those in the beet GlcCer group were observed. Oral administration of beet GlcCer had no obvious effects against an increase in TEWL or decrease in SC water content after UVB irradiation, but there was improvement in the beet extract group. Oral administration of beet GlcCer is effective in improving skin barrier function in UVB-irradiated mice. Beet extract contains constituents other than GlcCer that are also effective in improving skin barrier function.
从甜菜提取物中纯化的葡萄糖神经酰胺（甜菜 GlcCer）和含有等量 GlcCer 的甜菜提取物被口服给予紫外线 B（UVB）照射的小鼠，并比较它们对 UVB 照射引起的皮肤屏障功能障碍的保护作用的差异。在甜菜 GlcCer 组中，UVB 照射引起的表皮增厚和角质层（SC）神经酰胺含量减少得到了减轻。在口服给予含有葡萄糖神经酰胺的甜菜提取物的组中，观察到与甜菜 GlcCer 组相似的效果。口服给予甜菜 GlcCer 对 UVB 照射后 TEWL 的增加或 SC 含水量的减少没有明显作用，但在甜菜提取物组中有所改善。口服给予甜菜 GlcCer 可有效改善 UVB 照射小鼠的皮肤屏障功能。甜菜提取物含有除 GlcCer 以外的有效改善皮肤屏障功能的成分。
