饮用无糖汽水后三氯蔗糖和乙酰磺胺酸钾在母乳中的药代动力学。
Pharmacokinetics of Sucralose and Acesulfame-Potassium in Breast Milk Following Ingestion of Diet Soda.
作者信息
Rother Kristina I, Sylvetsky Allison C, Walter Peter J, Garraffo H Martin, Fields David A
机构信息
Section on Pediatric Diabetes and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Department of Exercise and Nutrition Sciences.
出版信息
J Pediatr Gastroenterol Nutr. 2018 Mar;66(3):466-470. doi: 10.1097/MPG.0000000000001817.
OBJECTIVE
The aim of this study was to determine sucralose and acesulfame-potassium (ace-K) pharmacokinetics in breast milk following maternal ingestion of a diet soda.
METHODS
Thirty-four exclusively breast-feeding women (14 normal-weight, 20 obese) consumed 12 ounces of Diet Rite Cola, sweetened with 68-mg sucralose and 41-mg ace-K, before a standardized breakfast meal. Habitual non-nutritional sweeteners intake was assessed via a diet questionnaire. Breast milk was collected from the same breast before beverage ingestion and hourly for 6 hours.
RESULTS
Owing to one mother having extremely high concentrations, peak sucralose and acesulfame-potassium concentrations following ingestion of diet soda ranged from 4.0 to 7387.9 ng/mL (median peak 8.1 ng/mL) and 299.0 to 4764.2 ng/mL (median peak 945.3 ng/mL), respectively.
CONCLUSIONS
Ace-K and sucralose transfer into breast milk following ingestion of a diet soda. Future research should measure concentrations after repeated exposure and determine whether chronic ingestion of sucralose and acesulfame-potassium via the breast milk has clinically relevant health consequences.
目的
本研究旨在确定母亲摄入无糖汽水后母乳中三氯蔗糖和乙酰磺胺酸钾（安赛蜜）的药代动力学。
方法
34名纯母乳喂养的女性（14名体重正常，20名肥胖）在标准化早餐前饮用了12盎司用68毫克三氯蔗糖和41毫克安赛蜜调味的健怡可乐。通过饮食问卷评估习惯性非营养甜味剂的摄入量。在饮用饮料前从同一侧乳房采集母乳，并在6小时内每小时采集一次。
结果
由于有一位母亲的浓度极高，摄入无糖汽水后三氯蔗糖和乙酰磺胺酸钾的峰值浓度分别为4.0至7387.9纳克/毫升（中位峰值8.1纳克/毫升）和299.0至4764.2纳克/毫升（中位峰值945.3纳克/毫升）。
结论
摄入无糖汽水后，安赛蜜和三氯蔗糖会转移到母乳中。未来的研究应测量反复接触后的浓度，并确定通过母乳长期摄入三氯蔗糖和乙酰磺胺酸钾是否会产生具有临床意义的健康后果。
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