墨西哥米却肯州女性人乳头瘤病毒的流行情况显示，异常病毒基因型的频率很高。
Prevalence of Human Papillomavirus in Women from the State of Michoacan, Mexico, Showed High Frequency of Unusual Virus Genotypes.
作者信息
Jácome-Galarza Irvin, Ito-Nakashimada María Ayumi, Figueroa-Aguilar Gloria, García-Latorre Ethel, Salazar Ma Isabel, López-Orduña Eduardo, Camacho Alejandro D, Valdez-Alarcón Juan José, Hernández José Manuel, León-Avila Gloria
机构信息
Molecular Biology, Laboratorio Estatal de Salud Pública de Michoacán, Morelia, Michoacán, Mexico.
Department of Zoology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
出版信息
Rev Invest Clin. 2017 Sep-Oct;69(5):262-269. doi: 10.24875/ric.17002065.
BACKGROUND
Human papillomaviruses (HPVs), the leading cause of cervical cancer, are distributed worldwide, with high prevalence in developing countries.
OBJECTIVE
The objective of the study is to know the prevalence and genotypes of HPV in women from the state of Michoacán and the Women's Hospital in Morelia, Michoacán.
MATERIALS AND METHODS
Cervical smear samples (159,288) were subjected to HPV detection by hybrid capture 2. A subsample of 484 patients from the Women's Hospital was studied by Papanicolaou test and linear array HPV genotyping, and when positive, patients were also examined by colposcopy and histopathology.
RESULTS
The overall prevalence for HPV in Michoacán State was 7.74%; 7.11% in 2009, 6.46% in 2010, 9.58% in 2011, and 8.43% in 2012. The highest prevalence was found in the age groups < 25 and 25-34 years. The prevalence at the Women's Hospital was 8.51%. Cytological examination revealed normal cytology in 64.44% of samples, 26.66 % with low-grade and 8.88 % with high-grade squamous intraepithelial lesion (HSIL). However, by colposcopy, normal tissue appearance was found only in 26.66%; 51% were reclassified as low-grade squamous intraepithelial lesion, 17.77% as HSIL, and in 4.4% atrophy was observed. The most prevalent genotype in single infections was HPV59, followed by HPV51 and HPV45. Double infections occurred with the following genotypes: 52-53, 51-59, 61-67, 66-11, 16-62, 53-62, 59-CP6108, 45-66, and 45-51. Triple infections were identified as: 6-31-39, 51-59-62, 51-62-81, 54-55-59, 16-58-71, and 16-59-62.
CONCLUSIONS
The prevalent genotype found among women from Michoacán, HPV59, was different to the rest of the country. The high prevalence of HPV59 could be due to cases imported to Michoacán by agricultural workers migrating to the USA or may be associated to ethnicity differences. Implications of this finding for immunization programs should be explored.
背景
人乳头瘤病毒（HPV）是宫颈癌的主要病因，在全球范围内均有分布，在发展中国家的感染率较高。
目的
本研究旨在了解米却肯州及米却肯州莫雷利亚市妇女医院女性中HPV的感染率及基因型。
材料与方法
对159,288份宫颈涂片样本采用杂交捕获2法进行HPV检测。对妇女医院的484例患者的子样本进行巴氏试验和线性阵列HPV基因分型研究，检测呈阳性的患者还需接受阴道镜检查和组织病理学检查。
结果
米却肯州HPV的总体感染率为7.74%；2009年为7.11%，2010年为6.46%，2011年为9.58%，2012年为8.43%。感染率最高的年龄组为<25岁和25 - 34岁。妇女医院的感染率为8.51%。细胞学检查显示，64.44%的样本细胞学正常，26.66%为低级别，8.88%为高级别鳞状上皮内病变（HSIL）。然而，通过阴道镜检查发现，只有26.66%的组织外观正常；51%被重新分类为低级别鳞状上皮内病变，17.77%为HSIL，4.4%观察到萎缩。单一感染中最常见的基因型是HPV59，其次是HPV51和HPV45。双重感染的基因型如下：52 - 53、51 - 59、61 - 67、66 - 11、16 - 62、53 - 62、59 - CP6108、45 - 66和45 - 51。三重感染被鉴定为：6 - 31 - 39、51 - 59 - 62、51 - 62 - 81、54 - 55 - 59、16 - 58 - 71和16 - 59 - 62。
结论
在米却肯州女性中发现的最常见基因型HPV59与该国其他地区不同。HPV59的高感染率可能是由于农业工人移民到美国后将病例带入米却肯州，或者可能与种族差异有关。应探索这一发现对免疫计划的影响。
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