de Carvalho Isis Polianna Silva Ferreira, Peixoto Henry Maia, Romero Gustavo Adolfo Sierra, de Oliveira Maria Regina Fernandes
Centre for Tropical Medicine, University of Brasilia, Brasilia, Brazil.
University Centre of Brasilia, Brasilia, Brazil.
Trop Med Int Health. 2017 Dec;22(12):1579-1589. doi: 10.1111/tmi.12994. Epub 2017 Nov 20.
To estimate the Brazilian direct and indirect costs of human visceral leishmaniasis (VL) in 2014.
Cost-of-illness study on the Brazilian public health system and societal perspective. VL cases registered in the Notifiable Diseases Information System in the year of 2014 were considered. Direct medical costs regarding diagnostic, treatment and care provided to patients with VL were estimated through the top-down approach. The indirect costs related to productivity loss due to premature mortality and morbidity were estimated by means of the human-capital method.
In 2014, 9895 suspected cases of VL were reported in the Notifiable Diseases Information System, and 3453 were later confirmed. There were 234 patients with Leishmania-HIV coinfection underwent a secondary prophylaxis. The total cost of VL in Brazil was US$ 14 190 701.50 (US$ 14 189 150.10 to 14 199 940.53) that varied according to the sensitivity analysis. The total of direct medical costs corresponded to US$ 1 873 681.96 (US$1 872 130.55 to 1 882 920.99), and the majority of costs was associated with hospitalisation (40%), followed by treatment (22%), and secondary prophylaxis (18%). Productivity loss corresponded to US$ 11 421 683.37 for premature mortality and US$ 895 336.18 for work absence due to hospitalisation by the illness.
VL represents an expensive health problem for the Brazilian public health system and society, mainly because of its productivity loss due to premature mortality. Interventions to reduce VL lethality could have a great impact on decreasing the cost of illness.
估算2014年巴西内脏利什曼病(VL)的直接和间接成本。
从巴西公共卫生系统和社会角度进行疾病成本研究。纳入2014年法定传染病信息系统登记的VL病例。通过自上而下的方法估算为VL患者提供诊断、治疗和护理的直接医疗成本。采用人力资本法估算因过早死亡和发病导致的生产力损失相关的间接成本。
2014年,法定传染病信息系统报告了9895例疑似VL病例,其中3453例随后得到确诊。234例利什曼病合并艾滋病病毒感染患者接受了二级预防。巴西VL的总成本为14190701.50美元(14189150.10美元至14199940.53美元),根据敏感性分析有所不同。直接医疗成本总计1873681.96美元(1872130.55美元至1882920.99美元),大部分成本与住院相关(40%),其次是治疗(22%)和二级预防(18%)。过早死亡导致的生产力损失为11421683.37美元,因病住院导致的工作缺勤生产力损失为895336.18美元。
VL对巴西公共卫生系统和社会来说是一个成本高昂的健康问题,主要是因为过早死亡导致的生产力损失。降低VL致死率的干预措施可能对降低疾病成本产生重大影响。