Morais Viviane Aparecida Carvalho de, Tourino Marina Ferreira da Silva, Almeida Ana Carolina de Souza, Albuquerque Thaís Bueno Dias, Linhares Roberta Castro, Christo Paulo Pereira, Martinelli Patrícia Massara, Scalzo Paula Luciana
a Laboratório de Neurobiologia, Departamento de Morfologia , Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte , Brazil.
b Ambulatório de Neurologia , Centro de Especialidades Médicas da Santa Casa de Belo Horizonte , Belo Horizonte , Brazil.
Top Stroke Rehabil. 2018 Jan;25(1):1-5. doi: 10.1080/10749357.2017.1373500. Epub 2017 Oct 27.
Background Aerobic exercise, even for short durations, may promote an increase in serum concentrations of brain-derived neurotrophic factor (BDNF). However, it is necessary to determine the optimal exercise types and intensities to increase BDNF levels. Objectives This aim of this study was investigate the effects of mild and moderate intensity acute aerobic exercise on serum BDNF levels in patients in the chronic post-stroke phase. Methods The participants answered a socio-demographic questionnaire, cognitive assessment (Mini Mental State Examination), assessment of depressive symptoms (Hamilton Depression Scale), fatigue (Fatigue Severity Scale) and functional capacity (6-minute walk test). Blood samples were collected before and after each session. The measurement of the concentration of BDNF was performed using the enzyme-linked immunosorbent assay . Patients were asked to walk for 30-min in the target training zone (mild intensity, 50-63% of maximum heart rate, and moderate intensity, 64-76% of maximum heart rate), once each week for 2 consecutive weeks. Results Our results indicate that 30 min of acute aerobic exercise at a moderate intensity, but not at a mild intensity, increases serum BDNF levels in the chronic post-stroke phase. Conclusions This study suggests a potential mechanism for the beneficial effects of exercise as a component of recovery from stroke, and provides the basis for future studies that will elucidate the specific parameters for clinical applications.
背景 有氧运动，即使是短时间的，也可能促使血清脑源性神经营养因子（BDNF）浓度升高。然而，有必要确定能提高BDNF水平的最佳运动类型和强度。目的 本研究旨在探讨轻度和中度强度的急性有氧运动对慢性卒中后患者血清BDNF水平的影响。方法 参与者回答了一份社会人口统计学问卷、进行了认知评估（简易精神状态检查表）、抑郁症状评估（汉密尔顿抑郁量表）、疲劳评估（疲劳严重程度量表）和功能能力评估（6分钟步行试验）。每次运动前后采集血样。使用酶联免疫吸附测定法测量BDNF浓度。患者被要求在目标训练区域步行30分钟（轻度强度，最大心率的50 - 63%；中度强度，最大心率的64 - 76%），连续两周每周一次。结果 我们的结果表明，在慢性卒中后阶段，30分钟的中度强度急性有氧运动可提高血清BDNF水平，而轻度强度的运动则不能。结论 本研究提示了运动作为卒中恢复一部分所产生有益效果的潜在机制，并为未来阐明临床应用具体参数的研究提供了基础。
