Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94122, USA.
Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94122, USA; Medical Service, Department of Veteran Affairs Medical Center, San Francisco, CA 94121, USA.
Infect Dis Clin North Am. 2017 Dec;31(4):827-838. doi: 10.1016/j.idc.2017.07.014.
Hepatitis C virus (HCV) is the most common blood-borne infection in the United States and is of concern in older adults. HCV infection is associated with not only hepatic but also extrahepatic comorbidities common to the aging patient including diabetes, kidney and cardiovascular diseases, and neurocognitive impairment. The effect of direct-acting antiviral agents to treat HCV on these outcomes is limited. This article summarizes the literature regarding the epidemiology and natural history of HCV infection; the impact of age on clinical outcomes in HCV-infected persons; and current knowledge regarding safety and efficacy of HCV treatment regimens in the older patient.
丙型肝炎病毒（HCV）是美国最常见的血源感染病毒，也是老年人关注的问题。HCV 感染不仅与肝脏有关，还与老年患者常见的肝外合并症有关，包括糖尿病、肾脏和心血管疾病以及神经认知障碍。直接作用抗病毒药物治疗 HCV 对这些结果的影响是有限的。本文总结了关于 HCV 感染的流行病学和自然史的文献；年龄对 HCV 感染患者临床结局的影响；以及关于老年患者 HCV 治疗方案的安全性和疗效的现有知识。
