丙型肝炎无症状老年人的认知表现：教育的作用。
Cognitive Performance in Asymptomatic Elderly People with Hepatitis C: The Role of Education.
作者信息
Fakoury Max Kopti, Schmidt Sergio Luis, Brandão Mello Carlos Eduardo, Filho Aureo do Carmo, Amendola Pires Marcia Maria
机构信息
Department of Internal Medicine, Gaffrée and Guinle University Hospital, Federal University of the State of Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.
Graduate Program in Neurology, Department of Neurology, PPGNEURO-UNIRIO, Federal University of the State of Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.
出版信息
J Clin Med. 2023 Jul 10;12(14):4588. doi: 10.3390/jcm12144588.
BACKGROUND
Neurotropism of the hepatitis C virus (HCV) can be the source of subtle neuropsychological symptoms in non-cirrhotic patients. Age is a risk factor for cognitive impairment (CI). Thus, asymptomatic elderly people who carry HCV might be at a greater risk of CI. Education can influence test performance.
OBJECTIVES
(1) To verify whether elderly people with HCV performed poorer than controls on cognitive tests. (2) To analyze how education affects performance. (3) To verify whether the extent of the effect of education on performance depends on the group (HCV vs. controls) and the type of cognitive test.
METHODS
Asymptomatic HCV carriers older than 60 years ( = 41) were matched with 41 corresponding controls. All participants performed the following tests: Mini-Cog, Mini Mental State Examination, clock drawing test (CDT), and verbal fluency.
RESULTS
(1) There were no significant differences in cognitive performance between the two groups. (2) Higher education was always associated with better performance. (3) There was a significant group difference in the slopes of the regression lines between years of education and CDT performance. No differences were found for the other three tests.
CONCLUSION
Considering the scores on the CDT, the rate of improvement in performance when schooling increases is higher in HCV carriers.
背景
丙型肝炎病毒（HCV）的神经嗜性可能是非肝硬化患者细微神经心理症状的来源。年龄是认知障碍（CI）的一个危险因素。因此，携带HCV的无症状老年人可能患CI的风险更高。教育程度会影响测试表现。
目的
（1）验证携带HCV的老年人在认知测试中的表现是否比对照组差。（2）分析教育程度如何影响表现。（3）验证教育程度对表现的影响程度是否取决于组别（HCV组与对照组）和认知测试类型。
方法
将60岁以上的无症状HCV携带者（n = 41）与41名相应的对照组进行匹配。所有参与者都进行了以下测试：简易认知评估量表（Mini-Cog）、简易精神状态检查表（Mini Mental State Examination）、画钟试验（CDT）和语言流畅性测试。
结果
（1）两组在认知表现上没有显著差异。（2）教育程度越高，表现总是越好。（3）教育年限与CDT表现之间的回归线斜率存在显著的组间差异。其他三项测试未发现差异。
结论
考虑到CDT的得分，HCV携带者中随着受教育年限增加表现改善的速率更高。
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