Department Biostatistics, University Nebraska Medical Center, 42nd Street and Emile Street, Omaha, NE 68198, USA.
Endocrinology, Creighton University Medical School, 2400 California Plaza, Omaha, NE 68131, USA.
Endocrinol Metab Clin North Am. 2017 Dec;46(4):871-884. doi: 10.1016/j.ecl.2017.07.003. Epub 2017 Sep 29.
Vitamin D insufficiency and deficiency can be diagnosed with measurements of serum 25-hydroxyvitamin D (25OHD). Most vitamin D is derived from sunlight (80%), so serum 25OHD levels are lowest in late winter and early spring. Dietary vitamin D in North America is small, about 100 to 200 IU daily. A recent review of the literature shows many association studies relating vitamin D deficiency and insufficiency to several diseases. Large randomized trials of vitamin D are underway and soon there may be answers as to whether vitamin D is clinically effective and what level of serum 25OHD is necessary.
维生素 D 不足和缺乏可以通过测量血清 25-羟维生素 D（25OHD）来诊断。大多数维生素 D 来自阳光（80%），因此血清 25OHD 水平在冬末和早春最低。北美饮食中的维生素 D 含量很少，每天约 100 至 200IU。最近对文献的综述表明，许多与维生素 D 缺乏和不足相关的关联研究与多种疾病有关。正在进行维生素 D 的大型随机试验，很快就会有答案，说明维生素 D 是否在临床上有效，以及需要达到什么样的血清 25OHD 水平。
