Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy; Istituto Auxologico Italiano, Milano, Italy.
Department of Cardiology, Charité-University-Medicine Campus Virchow Klinikum, Berlin, Germany.
Pharmacol Res. 2018 Feb;128:315-321. doi: 10.1016/j.phrs.2017.10.003. Epub 2017 Oct 27.
Effective cardiovascular prevention in the hypertensive setting needs the achievement of a tight blood pressure (BP) control with appropriate lifestyle measures and anti-hypertensive therapy. In fact, the ultimate goal of treatment strategies is the reduction of the excess of cardiovascular mortality and morbidity related to chronically elevated BP. In this chapter we will review the recommendations provided by the latest ESH/ESC guidelines focusing on the non-pharmacological and pharmacological treatment of hypertension. The first part will be focalized on the BP targets to be achieved by the treatment in the general hypertensive population and in specific clinical settings. In the second part, we will also depict the life-style changes with proven anti-hypertensive efficacy. In the third part we will describe the general principles of pharmacological therapy recommended in the general population and in special conditions. Finally we will make a brief comment on the new hypertension guidelines that will be published in 2017.
有效的心血管疾病预防需要在高血压环境中实现严格的血压（BP）控制，包括适当的生活方式措施和抗高血压治疗。事实上，治疗策略的最终目标是降低与慢性血压升高相关的心血管死亡率和发病率的增加。在这一章中，我们将回顾最新的ESH/ESC 指南提供的建议，重点是高血压的非药物和药物治疗。第一部分将集中在治疗一般高血压人群和特定临床环境中应达到的 BP 目标。在第二部分，我们还将描述具有明确降压效果的生活方式改变。在第三部分，我们将描述在一般人群和特殊情况下推荐的药物治疗的一般原则。最后，我们将对 2017 年发布的新高血压指南进行简要评论。
