Research and Development, British American Tobacco Investments Ltd, Regents Park Road, Southampton, Hampshire SO15 8TL, UK.
Research and Development, British American Tobacco Investments Ltd, Regents Park Road, Southampton, Hampshire SO15 8TL, UK.
Regul Toxicol Pharmacol. 2018 Mar;93:14-33. doi: 10.1016/j.yrtph.2017.10.006. Epub 2017 Oct 25.
For a tobacco heating product (THP), which heats rather than burns tobacco, the emissions of toxicants in the aerosol were compared with those in cigarette smoke under a machine-puffing regimen of puff volume 55 ml, puff duration 2 s and puff interval 30 s. The list of toxicants included those proposed by Health Canada, the World Health Organization Study Group on Tobacco Product Regulation (TobReg), the US Food and Drug Administration and possible thermal breakdown products. In comparison to the University of Kentucky 3R4F reference cigarette the toxicant levels in the THP1.0 emissions were significantly reduced across all chemical classes. For the nine toxicants proposed by TobReg for mandated reduction in cigarette emissions, the mean reductions in THP1.0 aerosol were 90.6-99.9% per consumable with an overall average reduction of 97.1%. For the abbreviated list of harmful and potentially harmful constituents of smoke specified by the US Food and Drug Administration Tobacco Products Scientific Advisory Committee for reporting in cigarette smoke (excluding nicotine), reductions in the aerosol of THP1.0 were 84.6-99.9% per consumable with an overall average reduction of 97.5%.
对于一种加热而非燃烧烟草的加热烟草制品（THP），在抽吸体积为 55ml、抽吸持续时间为 2s 和抽吸间隔为 30s 的机器抽吸方案下，比较了气溶胶中有毒物质的排放与香烟烟雾中的排放。有毒物质清单包括加拿大卫生部、世界卫生组织烟草制品监管研究小组（TobReg）、美国食品和药物管理局以及可能的热分解产物所提议的有毒物质。与肯塔基大学 3R4F 参考香烟相比，THP1.0 排放物中的有毒物质水平在所有化学类别中均显著降低。对于 TobReg 提议为减少香烟排放而强制减少的九种有毒物质，THP1.0 气溶胶中的平均减少量为每个消耗品 90.6-99.9%，总体平均减少量为 97.1%。对于美国食品和药物管理局烟草制品科学咨询委员会规定的香烟烟雾中报告的烟雾中有害和潜在有害成分的缩写清单（不包括尼古丁），THP1.0 气溶胶中的减少量为每个消耗品 84.6-99.9%，总体平均减少量为 97.5%。
