Shiba Kiyotaka
Division of Protein Engineering, The Cancer Institute of Japanese Foundation for Cancer Research, Ariake, Koto, Tokyo, 135-8550, Japan.
Adv Exp Med Biol. 2017;1030:1-20. doi: 10.1007/978-3-319-66095-0_1.
A peptide can be used as a functional building block to construct artificial systems when it has sufficient transplantability and functional independence in terms of its assigned function. Recent advances in in vitro evolution systems have been increasing the list of peptides that specifically bind to certain targets, such as proteins and cells. By properly displaying these peptides on solid surfaces, we can endow the inorganic materials with various biological functions, which will contribute to the development of diagnosis and therapeutic medical devices. Here, the methods for the peptide-based surface functionalization are reviewed by focusing on sources of peptides as well as methods of immobilization.
当一种肽在其指定功能方面具有足够的可移植性和功能独立性时，它可以用作构建人工系统的功能组件。体外进化系统的最新进展不断增加了能特异性结合某些靶标（如蛋白质和细胞）的肽的种类。通过在固体表面适当展示这些肽，我们可以赋予无机材料各种生物学功能，这将有助于诊断和治疗医疗设备的开发。在此，通过关注肽的来源以及固定方法，对基于肽的表面功能化方法进行综述。
