van Leeuwen T H, Verbaten M N, Koelega H S, Camfferman G, van der Gugten J, Slangen J L
Faculty of Pharmacy, Department of Psychopharmacology Rudolf Magnus Institute of Neuroscience, Utrecht University, The Netherlands.
Psychopharmacology (Berl). 1994 Feb;114(1):109-18. doi: 10.1007/BF02245451.
The aim of the present study was to determine whether in a task with stimuli inducing frequent saccadic eye movements, ingestion of oxazepam impairs performance more than in a task in which the stimuli remained fixed at the same location, due to effects of oxazepam on the ocular system. Eighteen males performed a vigilance task with static and dynamic stimuli under the influence of oxazepam (20 and 40 mg) in a placebo-controlled, double blind, crossover design. Oxazepam (40 mg) had a larger effect on vigilance performance in the first part of the dynamic task, relative to its static counterpart. Oxazepam also had an effect on oculomotor behavior, but this effect was unrelated to impaired performance. There were dose-dependent effects of oxazepam on absolute, overall level of performance but not on the decrement with time. The non-dose-dependent aggravation of the decrement in correct detections, caused by the drug, could only partly be accounted for by pharmacokinetics and increased eyelid closures, and was also caused by pharmacodynamic effects of the drug, such as those on attention. Different effects were noted for the two signal detection measures of response behavior, B" and RI.
本研究的目的是确定在一项伴有诱发频繁眼球跳动刺激的任务中，由于奥沙西泮对眼部系统的影响，奥沙西泮的摄入是否比在刺激保持固定在同一位置的任务中对表现的损害更大。18名男性在安慰剂对照、双盲、交叉设计下，于奥沙西泮（20毫克和40毫克）影响下完成了一项伴有静态和动态刺激的警觉任务。相对于静态任务，奥沙西泮（40毫克）在动态任务的第一部分对警觉表现有更大影响。奥沙西泮对眼球运动行为也有影响，但这种影响与表现受损无关。奥沙西泮对绝对总体表现水平有剂量依赖性影响，但对随时间的下降没有影响。药物引起的正确检测下降的非剂量依赖性加重，部分可由药代动力学和眼睑闭合增加来解释，也由药物的药效学作用引起，比如对注意力的影响。对反应行为的两种信号检测指标B"和RI观察到了不同的影响。
