Artigas José M, García-Domene M Carmen, Navea Amparo, Botella Pablo, Fernández Eduardo
Fisabio Oftalmología Médica (FOM), Bifurcación Pío Baroja-General Avilés s/n, 46015 Valencia, Spain.
Depto de Óptica, Facultad de Física, Universitat de València, C/Dr Moliner, 50, 46100 Burjassot (Valencia), Spain.
Biomed Opt Express. 2017 Sep 21;8(10):4621-4628. doi: 10.1364/BOE.8.004621. eCollection 2017 Oct 1.
To study the optical changes on hydrogel-silicone intraocular lenses (IOLs) resulting from loading them with dexamethasone. We used prototype hydrogel(pHEMA)-silicone IOLs and loaded the matrices with an anti-inflammatory drug (dexamethasone). The optical properties we analyzed experimentally were a) modulation transfer function (MTF); b) spectral transmission; c) diopter power. These determinations were performed on drug-loaded IOLs, IOLs that had released the drug, and IOLs that had not been drug-loaded. Loading a hydrogel-silicone IOL with dexamethasone results in impairment of its optical qualities, in particular its MTF and spectral transmission, but not dioptric power. However, once the drug has been released, it almost recovers its initial optical properties.
研究向水凝胶-硅酮人工晶状体（IOL）中加载地塞米松后其光学特性的变化。我们使用了原型水凝胶（聚甲基丙烯酸羟乙酯，pHEMA）-硅酮人工晶状体，并在基质中加载了一种抗炎药物（地塞米松）。我们通过实验分析的光学特性包括：a）调制传递函数（MTF）；b）光谱透射率；c）屈光度。这些测定是在加载药物的人工晶状体、已释放药物的人工晶状体以及未加载药物的人工晶状体上进行的。向水凝胶-硅酮人工晶状体中加载地塞米松会导致其光学质量受损，特别是其MTF和光谱透射率，但屈光度不受影响。然而，一旦药物释放，它几乎能恢复其初始光学特性。
