使用短TR绝热反转恢复（STAIR）序列对髓鞘和髓鞘水的年龄相关变化进行量化。
Age-related changes in myelin and myelin water quantified with short-TR adiabatic inversion-recovery (STAIR) sequences.
作者信息
Lo James, Wang Jiaji, Tran Dylan, Nemeh Gabrielle, Liu Brandon, Shin Soo Hyun, Athertya Jiyo S, Schiehser Dawn, Ma Yajun, Du Jiang
机构信息
Department of Radiology, University of California, San Diego, CA, USA; Department of Bioengineering, University of California, San Diego, CA, USA.
Department of Radiology, University of California, San Diego, CA, USA.
出版信息
Neuroimage Clin. 2025;46:103801. doi: 10.1016/j.nicl.2025.103801. Epub 2025 May 9.
Myelin proton density fraction (MPDF) and myelin water fraction (MWF) measured with short-TR adiabatic inversion-recovery (STAIR) sequences are potential biomarkers of aging and neurodegeneration, but the effects of aging on MPDF/MWF remain unknown. This study aims to assess relationships between age and MPDF/MWF using the 3D STAIR ultrashort echo time (STAIR-UTE) and STAIR short echo time (STAIR-STE) sequences, respectively. 42 volunteers (29 young (<55y), 13 old (>55y)), were recruited for MPDF and MWF mapping for white matter (WM) and gray matter (GM) on a 3 T scanner. Excellent inter-reader reliability was demonstrated for MPDF and MWF measurements with ICC values of 0.97 and 0.98, respectively, between two readers. In the young group, WM MPDF and MWF range from 8-13 % and 6-13 %, respectively, while GM MPDF and MWF range from 5-7 % and 3-5 %, respectively. In the old group, WM MPDF and MWF range from 6-12 % and 5-13 %, and GM MPDF and MWF range from 3-6 % and 2-5 %, respectively. The young group's MPDF/MWF values were significantly higher than those of the old group. Altogether, the 42 volunteers display linear and quadratic associations of MPDF/MWF with age. MPDF demonstrated significant correlations with MWF in the majority of brain regions. This study demonstrates the capability of two myelin imaging biomarkers, STAIR-UTE measured MPDF and STAIR-STE measured MWF to map brain myelin and MW. These biomarkers hold the potential to differentiate normal aging from neuroinflammatory/neurodegenerative diseases.
用短TR绝热反转恢复（STAIR）序列测量的髓磷脂质子密度分数（MPDF）和髓磷脂水分数（MWF）是衰老和神经退行性变的潜在生物标志物，但衰老对MPDF/MWF的影响尚不清楚。本研究旨在分别使用3D STAIR超短回波时间（STAIR-UTE）和STAIR短回波时间（STAIR-STE）序列评估年龄与MPDF/MWF之间的关系。招募了42名志愿者（29名年轻人（<55岁），13名老年人（>55岁）），在3T扫描仪上对脑白质（WM）和脑灰质（GM）进行MPDF和MWF成像。两名阅片者之间MPDF和MWF测量的阅片者间可靠性极佳，ICC值分别为0.97和0.98。在年轻组中，WM的MPDF和MWF分别为8%-13%和6%-13%，而GM的MPDF和MWF分别为5%-7%和3%-5%。在老年组中，WM的MPDF和MWF分别为6%-12%和5%-13%，GM的MPDF和MWF分别为3%-6%和2%-5%。年轻组的MPDF/MWF值显著高于老年组。总体而言，42名志愿者的MPDF/MWF与年龄呈线性和二次关联。在大多数脑区，MPDF与MWF显著相关。本研究证明了两种髓磷脂成像生物标志物，即STAIR-UTE测量的MPDF和STAIR-STE测量的MWF用于绘制脑髓磷脂和MW的能力。这些生物标志物有可能区分正常衰老与神经炎症/神经退行性疾病。
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