Landi F, Calvani R, Tosato M, Martone A M, Picca A, Ortolani E, Savera G, Salini S, Ramaschi M, Bernabei R, Marzetti E
Francesco Landi, MD, PhD - Center for Geriatric Medicine [CEMI), Institute of Internal Medicine and Geriatrics, Catholic University of the Sacred Heart, L.go F. Vito 8, Rome 00168, Italy. Phone: +39 (06) 3388546, Fax: +39 (06) 3051-911, e-mail:
J Nutr Health Aging. 2017;21(9):1050-1056. doi: 10.1007/s12603-017-0974-4.
Behavioral factors, including protein intake, influence the quantity and quality of skeletal muscle. The aim of this study was to explore the relationship between animal-derived protein intake and muscle mass and function in a large sample of unselected community-dwellers.
The VIP (Very Important Protein) study, conducted during Expo 2015 in Milan, was a population survey aimed at assessing major health metrics in a population outside of the research setting, with a special focus on the relation between animal-derived protein intake and muscle mass and function. A brief questionnaire exploring lifestyle habits, dietary preferences and the consumption of selected foods was administered. Muscle mass was estimated by calf circumference (CC) and mid-arm muscle circumference (MAMC) of the dominant side. Muscle strength of upper and lower extremities was assessed through handgrip strength testing and repeated chair stand test, respectively.
The mean age of the 1,853 participants was 50.3 years (standard deviation: 15.7; range: 18-98 years), of whom 959 (51.7%) were women. Participants in the highest tertile of protein consumption showed better performance at both the handgrip strength (p <0.001) and chair stand tests than those in the lowest tertile (p <0.01). The same results were found for CC (p <0.001) and MAMC (p <0.001). Participants with high protein intake and engaged in regular physical activity showed the higher scores in all the assessed domains.
The results of the VIP survey suggest an association between animal-derived protein intake and muscle mass and strength across ages. Our findings also indicate a synergistic effect of animal-derived protein intake and physical activity on muscle-related parameters.
行为因素，包括蛋白质摄入量，会影响骨骼肌的数量和质量。本研究的目的是在大量未经挑选的社区居民样本中探索动物源性蛋白质摄入量与肌肉质量和功能之间的关系。
在2015年米兰世博会期间开展的VIP（非常重要的蛋白质）研究是一项人群调查，旨在评估研究环境之外人群的主要健康指标，特别关注动物源性蛋白质摄入量与肌肉质量和功能之间的关系。发放了一份简短问卷，用以探究生活方式习惯、饮食偏好和特定食物的消费情况。通过优势侧小腿围（CC）和上臂中部肌肉围（MAMC）来估算肌肉质量。分别通过握力测试和重复起坐测试评估上肢和下肢的肌肉力量。
1853名参与者的平均年龄为50.3岁（标准差：15.7；范围：18 - 98岁），其中959名（51.7%）为女性。蛋白质摄入量处于最高三分位数的参与者在握力测试（p <0.001）和起坐测试中的表现均优于最低三分位数的参与者（p <0.01）。CC（p <0.001）和MAMC（p <0.001）也得到了相同的结果。高蛋白摄入量且经常进行体育锻炼的参与者在所有评估领域的得分更高。
VIP调查结果表明，动物源性蛋白质摄入量与各年龄段的肌肉质量和力量之间存在关联。我们的研究结果还表明，动物源性蛋白质摄入量和体育锻炼对肌肉相关参数具有协同作用。
