Saleh Haitham M., Zito Patrick M.
Department of Dermatology, Ain Shams University
University of Miami; Miller School of Medicine
Acne fulminans, also known as acne maligna, is a rare skin disorder characterized by an acute, painful, ulcerative, and hemorrhagic clinical form of acne. This condition may or may not be associated with systemic symptoms, such as fever and polyarthritis. In some cases, the condition can also lead to bone lesions and laboratory abnormalities. Acne fulminans is often confused with acne conglobata. This condition is typically resistant to the usual acne antibiotics. The term was introduced by Plewig and Kligman in 1975, highlighting its abrupt onset and severity. Traditionally, acne fulminans has been categorized into two types based on systemic involvement—acne fulminans and acne fulminans sine fulminans, the latter indicating the absence of systemic involvement. Recently, 4 clinical variations have been identified— acne fulminans with systemic symptoms, acne fulminans without systemic symptoms, isotretinoin-induced acne fulminans with systemic symptoms, and isotretinoin-induced acne fulminans without systemic symptoms.
暴发性痤疮,也称为恶性痤疮,是一种罕见的皮肤疾病,其特征为痤疮呈现急性、疼痛、溃疡性和出血性的临床形式。这种病症可能伴有或不伴有全身症状,如发热和多关节炎。在某些情况下,该病症还可导致骨病变和实验室检查异常。暴发性痤疮常与聚合性痤疮相混淆。这种病症通常对常用的痤疮抗生素耐药。该术语由普莱维希和克利格曼于1975年提出,强调其发病突然和病情严重。传统上,暴发性痤疮根据是否累及全身分为两型——暴发性痤疮和无全身症状的暴发性痤疮,后者表示无全身受累。最近,已确定了4种临床变异型——伴有全身症状的暴发性痤疮、无全身症状的暴发性痤疮、异维A酸诱导的伴有全身症状的暴发性痤疮和异维A酸诱导的无全身症状的暴发性痤疮。