Li Alvin W, Antaya Richard J
School of Medicine, Yale University, New Haven, CT, USA.
Department of Dermatology, School of Medicine, Yale University, New Haven, CT, USA.
Pediatr Dermatol. 2018 Mar;35(2):257-258. doi: 10.1111/pde.13389. Epub 2018 Jan 4.
Acne fulminans is a severe form of acne characterized by painful, inflammatory nodules that progress into ulcers and concurrent systemic symptoms. Treatment of acne with isotretinoin can precipitate a syndrome called isotretinoin-induced acne fulminans without systemic symptoms. An exuberant granulation tissue response, another known adverse event associated with isotretinoin, can occur concurrently, inhibiting wound repair and complicating treatment. We report a case of isotretinoin-induced acne fulminans without systemic symptoms with exuberant granulation tissue response that was treated successfully with topical clobetasol ointment.
暴发性痤疮是一种严重的痤疮形式，其特征为疼痛性炎性结节，可发展为溃疡并伴有全身症状。用异维A酸治疗痤疮可引发一种无全身症状的异维A酸诱导的暴发性痤疮综合征。另一种与异维A酸相关的已知不良事件——过度增生性肉芽组织反应，可同时发生，抑制伤口修复并使治疗复杂化。我们报告一例无全身症状的异维A酸诱导的暴发性痤疮伴有过度增生性肉芽组织反应的病例，该病例用外用氯倍他索软膏成功治愈。
