Goldschmidt H, Leyden J J, Stein K H
Arch Dermatol. 1977 Apr;113(4):444-9. doi: 10.1001/archderm.113.4.444.
Eight cases of acne fulminans (acute febrile ulcerative acne) are compared with 13 previously reported cases. This rare disorder of male teenage patients is characterized by the sudden appearance of highly inflammatory, tender, ulcerative and crusted lesions on the back, chest, and face: it is one of the most scarring acute dermatologic disorders of young patients. At the onset of the disease, all patients showed febrile temperatures and marked leukocytosis; other systemic symptoms occurred with varying frequency. Polyarthralgia was noted in half of our series. Investigations of potential trigger mechanisms (eg, septisemia due to Corynebacterium acnes, immunologic defects, altered polymorphonuclear leukocyte function, Shwartzman phenomenon) did not yield any clues regarding the pathogenesis of this disease. Clinical and laboratory findings suggest that acne fulminans is not directly related to acne conglobata.
将8例暴发性痤疮（急性发热性溃疡性痤疮）与之前报道的13例病例进行了比较。这种男性青少年患者的罕见疾病的特征是背部、胸部和面部突然出现高度炎症性、压痛性、溃疡性和结痂性病变：它是年轻患者中最易导致瘢痕形成的急性皮肤病之一。在疾病发作时，所有患者均表现出发热和明显的白细胞增多；其他全身症状出现的频率各不相同。在我们的系列病例中，有一半出现了多关节痛。对潜在触发机制（如痤疮丙酸杆菌败血症、免疫缺陷、多形核白细胞功能改变、施瓦茨曼现象）的调查未得出有关该疾病发病机制的任何线索。临床和实验室检查结果表明，暴发性痤疮与聚合性痤疮无直接关系。
