对呋喃唑酮和左氧氟沙星的耐药性：一种观点。
Resistance of to furazolidone and levofloxacin: A viewpoint.
作者信息
Zamani Mohammad, Rahbar Arash, Shokri-Shirvani Javad
机构信息
Student Research Committee, Babol University of Medical Sciences, Babol 47176-47745, Iran.
Department of Internal Medicine, Babol University of Medical Sciences, Babol 47176-47745, Iran.
出版信息
World J Gastroenterol. 2017 Oct 7;23(37):6920-6922. doi: 10.3748/wjg.v23.i37.6920.
In their review, Arslan et al did not describe the status of () treatment with furazolidone and the resistance to this antibiotic. We have presented different surveys showing the resistance of to furazolidone from Asia and South America. The resistance rates varied but were mostly low (< 5%). There are not enough data on its efficacy and resistance in the United States and Europe. mutations occurring in the gene, including A041G, A122G, C349A(G), A78G, A112G, A335G, C156T and C165T, and in the gene, including G353A, A356G, C357T, C347T, C347G and C346A, have been indicated to be possibly related to the observed resistance. Additionally, to complete Arslan et al's statement regarding levofloxacin resistance, it should be noted that compound mutations of N87A, A88N and V65I at codon Asn-87 were recently observed in the gene for the first time. However, the results on these topics are not sufficient, and more worldwide studies are suggested.
在他们的综述中，阿尔斯兰等人未描述用呋喃唑酮治疗的状况以及对这种抗生素的耐药性。我们展示了不同的调查，显示了来自亚洲和南美洲的[具体研究对象]对呋喃唑酮的耐药性。耐药率各不相同，但大多较低（<5%）。在美国和欧洲，关于其疗效和耐药性的数据不足。已表明在[具体基因]中发生的突变，包括A041G、A122G、C349A(G)、A78G、A112G、A335G、C156T和C165T，以及在[另一个具体基因]中发生的突变，包括G353A、A356G、C357T、C347T、C347G和C346A，可能与观察到的耐药性有关。此外，为完善阿尔斯兰等人关于左氧氟沙星耐药性的陈述，应当指出，最近首次在[具体基因]中观察到密码子Asn - 87处N87A、A88N和V65I的复合突变。然而，关于这些主题的结果并不充分，建议开展更多的全球研究。
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