伊朗大不里士市患者分离出的幽门螺杆菌菌株的抗生素耐药模式以及cagA和vacA基因的频率
Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran.
作者信息
Rasi-Bonab Farnaz, Jafari-Sales Abolfazl, Shaverdi Mohammad Amin, Navidifar Tahereh, Saki Morteza, Ghorbani Atosa, Adekanmbi Abimbola Olumide, Jafari Behboud, Naebi Sara
机构信息
Department of Microbiology, Marand Branch, Islamic Azad University, Marand, Iran.
Department of Microbiology, School of Basic Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran.
出版信息
BMC Res Notes. 2021 May 31;14(1):216. doi: 10.1186/s13104-021-05633-5.
Abstract
OBJECTIVE
Helicobacter pylori is one of the most common causes of gastric infections in humans. It is estimated that approximately 50% of people around the world are infected with this bacterium. This study aimed to determine the antibiotic resistance pattern, as well as the frequency of cagA and vacA genes in H. pylori isolates obtained from patients in the clinical centers in Tabriz city, Iran.
RESULTS
The culture method detected 100 (45.25%) H. pylori isolates from 221 biopsy samples during 3 years. The results showed that 63% and 81% of the isolates were positive for cagA and vacA genes, respectively. The highest resistance of isolates was seen against metronidazole (79%) and amoxicillin (36%), respectively. Also, the isolates showed the least resistance to tetracycline (8%).
摘要
目的
幽门螺杆菌是人类胃部感染最常见的病因之一。据估计，全球约50%的人感染了这种细菌。本研究旨在确定从伊朗大不里士市临床中心患者中分离出的幽门螺杆菌菌株的抗生素耐药模式以及cagA和vacA基因的频率。
结果
在3年期间，培养法从221份活检样本中检测出100株（45.25%）幽门螺杆菌菌株。结果显示，分别有63%和81%的菌株cagA和vacA基因呈阳性。分离菌株对甲硝唑（79%）和阿莫西林（36%）的耐药性最高。此外，分离菌株对四环素的耐药性最低（8%）。
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