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Association between a 10 kb Pvu II restriction fragment of genomic DNA with the hemochromatosis gene.

作者信息

Lucotte G, Coulondre C

机构信息

Laboratoire de Génétique Moléculaire, CNTS-Institut, Paris, France.

出版信息

Exp Clin Immunogenet. 1986;3(4):219-23.

PMID:2908538
Abstract

This study concerns the association between the hemochromatosis susceptibility gene and a 10 kb Pvu II HLA-class I specific restriction fragment. Forty Pvu II fragments are detected after hybridization with A3 or B7 probes, and 20 among them are polymorphic. The 10 kb polymorphic Pvu II fragment correlates absolutely with the A3 serological allele and patients with hemochromatosis, heterozygous or homozygous for A3, have the 10 kb Pvu II band.

摘要

相似文献

1
Association between a 10 kb Pvu II restriction fragment of genomic DNA with the hemochromatosis gene.
Exp Clin Immunogenet. 1986;3(4):219-23.
2
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引用本文的文献

1
HLA class I gene polymorphism in genetic hemochromatosis.遗传性血色素沉着症中的HLA I类基因多态性
Hum Genet. 1990 Aug;85(3):279-82. doi: 10.1007/BF00206746.